与病变性癫痫相关的共同脑网络的鉴定

IF 1.2 Q4 CLINICAL NEUROLOGY Acta Epileptologica Pub Date : 2023-11-01 DOI:10.1186/s42494-023-00138-z
Di Wu, Jinghui Liu, Liankun Ren
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引用次数: 0

摘要

中风是全球神经系统疾病的主要原因。值得注意的是,癫痫是卒中的常见并发症,严重影响患者的生活质量,给临床带来重大挑战。因此,更好地了解中风后癫痫的危险因素是至关重要的。最近发表在JAMA Neurology上的一项研究研究了76名患者与625名对照患者的脑卒中后癫痫相关的脑网络。结果表明,基底神经节和小脑损伤部位和区域之间的负功能连接增加了中风后发生癫痫的风险。与癫痫相关的病变网络节点在不同的病变类型(包括血肿、创伤、肿瘤和结节)中是相同的。此外,脑卒中后癫痫脑网络与深部脑刺激(DBS)具有潜在的治疗相关性。在一组30例患者中,发现丘脑前侧DBS部位和病变网络节点之间的功能连通性与DBS后癫痫发作控制相关。总之,这一发现为预测脑卒中后癫痫患者的风险提供了一种新的方法,并可能指导癫痫的脑刺激治疗。
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Identification of a common brain network associated with lesional epilepsy
Abstract Stroke is the leading cause of neurological diseases globally. Remarkably, epilepsy is a common complication of stroke, which greatly impairs the quality of life of patients and poses a significant clinical challenge. Therefore, a better understanding of the risk factors for poststroke epilepsy is crucial. A recent study published in JAMA Neurology studied the brain network associated with poststroke epilepsy in a group of 76 patients compared to a cohort of 625 control patients using lesion mapping techniques. The results showed that negative functional connectivity between lesion locations and regions in the basal ganglia and cerebellum confers a higher risk of developing epilepsy after stroke. The lesion network nodes associated with epilepsy were identical across different lesion types including hematomas, traumas, tumors, and tubers. Furthermore, the poststroke epilepsy brain network has potential therapeutic relevance to deep brain stimulation (DBS). In a cohort of 30 patients, the functional connectivity between anterior thalamic DBS sites and the lesion network nodes was found to correlate with seizure control after DBS. In summary, the finding provides a novel method for predicting the risk of poststroke epilepsy in patients and may guide brain stimulation treatments for epilepsy.
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来源期刊
Acta Epileptologica
Acta Epileptologica Medicine-Neurology (clinical)
CiteScore
2.00
自引率
0.00%
发文量
38
审稿时长
20 weeks
期刊最新文献
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