Struma ovarii associated with increased serum thyroglobulin

A 36-year-old woman with papillary thyroid cancer was diagnosed with a right ovarian mass ultrasonographically 2 years earlier. The mass increased in size gradually, and serum thyroglobulin (Tg) levels increased simultaneously to 1002.36 ng/mL; cancer antigen 125 levels remained normal. Preoperative ultrasonography demonstrated a right ovarian mass (6.3 × 5.2 × 3.8 cm) (Figure 1a, Video S1) consisting of homogeneous solid components and multiple follicles (Figure 1b). The mass exhibited high vascularity on color Doppler (Figure 1c). These features highly suggested struma ovarii (SO) and were consistent with magnetic resonance imaging findings. Single-port laparoscopic right adnexectomy was performed, with ascites seen in the pouch of Douglas (Figure 1d). The right ovary was fully occupied by a tumor (Figure 1e) containing grayish-brown gelatinous material (Figure 1f). Pathological examination confirmed SO. The serum Tg level decreased to normal 2 months after laparoscopy, which suggested SO as an extraglandular source of Tg.

Na Su: Data curation (lead); writing – original draft (equal). Fei Ji: Conceptualization (equal); writing – original draft (equal). Yang Cao: Conceptualization (equal); supervision (equal). Dan Wang: Supervision (equal). Meng Yang: Writing – review & editing (lead).

The authors declare no conflicts of interest.

Not applicable.

Not applicable.