纳米传感器化学细胞测量法:细胞疗法和精准医学的进步与机遇

IF 4.6 Q1 CHEMISTRY, ANALYTICAL ACS Measurement Science Au Pub Date : 2023-11-01 DOI:10.1021/acsmeasuresciau.3c00038
Youngho Song, Changyu Tian, Yullim Lee, Minyeong Yoon, Sang Eun Yoon and Soo-Yeon Cho*, 
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摘要

随着治疗学的定义已涵盖移植或工程细胞及其分子产物,科学界越来越需要通过分析来了解这一新的药物类别。本视角重点介绍无标记单细胞分析、纳米传感器化学细胞仪(NCC)等新型测量科学的最新发展及其在细胞疗法和精准医疗方面的潜力。NCC 基于集成了荧光纳米传感器阵列的微流体技术,利用单细胞的光学透镜效应实时提取分子特性,并将其与单细胞的物理属性相关联。这种新型细胞测量技术可以完全无标记和无损的方式量化细胞群的多元物理化学属性的异质性,从而为安全的治疗应用提供静脉到静脉条件的建议。在介绍了 NCC 技术之后,我们为新领域的成熟提出了技术发展路线图:从传感器/芯片设计角度到基于硬件自动化和深度学习数据分析的系统/软件开发层面。预计这种新型单细胞传感技术的进步将有助于丰富的多变量单细胞数据设置,并为安全可靠的细胞疗法提供支持。这一新的测量科学可实现数据驱动的个性化精准医疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Nanosensor Chemical Cytometry: Advances and Opportunities in Cellular Therapy and Precision Medicine

With the definition of therapeutics now encompassing transplanted or engineered cells and their molecular products, there is a growing scientific necessity for analytics to understand this new category of drugs. This Perspective highlights the recent development of new measurement science on label-free single cell analysis, nanosensor chemical cytometry (NCC), and their potential for cellular therapeutics and precision medicine. NCC is based on microfluidics integrated with fluorescent nanosensor arrays utilizing the optical lensing effect of a single cell to real-time extract molecular properties and correlate them with physical attributes of single cells. This new class of cytometry can quantify the heterogeneity of the multivariate physicochemical attributes of the cell populations in a completely label-free and nondestructive way and, thus, suggest the vein-to-vein conditions for the safe therapeutic applications. After the introduction of the NCC technology, we suggest the technological development roadmap for the maturation of the new field: from the sensor/chip design perspective to the system/software development level based on hardware automation and deep learning data analytics. The advancement of this new single cell sensing technology is anticipated to aid rich and multivariate single cell data setting and support safe and reliable cellular therapeutics. This new measurement science can lead to data-driven personalized precision medicine.

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来源期刊
ACS Measurement Science Au
ACS Measurement Science Au 化学计量学-
CiteScore
5.20
自引率
0.00%
发文量
0
期刊介绍: ACS Measurement Science Au is an open access journal that publishes experimental computational or theoretical research in all areas of chemical measurement science. Short letters comprehensive articles reviews and perspectives are welcome on topics that report on any phase of analytical operations including sampling measurement and data analysis. This includes:Chemical Reactions and SelectivityChemometrics and Data ProcessingElectrochemistryElemental and Molecular CharacterizationImagingInstrumentationMass SpectrometryMicroscale and Nanoscale systemsOmics (Genomics Proteomics Metabonomics Metabolomics and Bioinformatics)Sensors and Sensing (Biosensors Chemical Sensors Gas Sensors Intracellular Sensors Single-Molecule Sensors Cell Chips Arrays Microfluidic Devices)SeparationsSpectroscopySurface analysisPapers dealing with established methods need to offer a significantly improved original application of the method.
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Issue Publication Information Issue Editorial Masthead Development of Simple and Rapid Bead-Based Cytometric Immunoassays Using Superparamagnetic Hybrid Core–Shell Microparticles Colorimetric Hybridization Sensor for DNA Mimic of a SARS-CoV-2 RNA Marker: Direct and Inverse Bioanalysis Super-Resolution Microscopic Imaging of Lipid Droplets in Living Cells via Carbonized Polymer Dot-Based Polarity-Responsive Nanoprobe
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