利用溶液核磁共振探究金纳米粒子配体结构与动力学关系的变化

IF 4.8 Q2 NANOSCIENCE & NANOTECHNOLOGY ACS Nanoscience Au Pub Date : 2023-11-08 DOI:10.1021/acsnanoscienceau.3c00042
Rui Huang, Stefano Fedeli, Cristina-Maria Hirschbiegel, Xianzhi Zhang and Vincent M. Rotello*, 
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引用次数: 0

摘要

配体动力学对金纳米粒子(AuNPs)的化学和生物特性起着至关重要的作用。本研究使用了具有疏水性烷硫醇内部和亲水性外壳的配体,以系统地研究配体头基对配体动力学的影响。溶液核磁共振(NMR)光谱提供了对单层配体动力学的定量洞察。值得注意的是,在阳离子头基团中引入疏水分子会显著降低配体的构象流动性;然而,这些疏水分子之间的疏水性差异对这种降低的影响有限。在离子强度和温度等各种生理条件下对配体动态的进一步研究表明,随着离子强度的增加或温度的降低,与 AuNP 表面结合的配体的构象流动性会降低。对配体动力学的探索为设计适合特定生物应用的纳米粒子提供了启示。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Modulation of Gold Nanoparticle Ligand Structure–Dynamic Relationships Probed Using Solution NMR

Ligand dynamics plays a critical role in the chemical and biological properties of gold nanoparticles (AuNPs). In this study, ligands featuring hydrophobic alkanethiol interiors and hydrophilic shells were used to systematically examine the effects of ligand headgroups on the ligand dynamics. Solution nuclear magnetic resonance (NMR) spectroscopy provided quantitative insight into the monolayer ligand dynamics. Notably, the introduction of hydrophobic moieties to the cationic headgroups significantly decreased ligand conformational mobility; however, variations in hydrophobicity among these moieties had a limited effect on this reduction. Further examination of ligand dynamics under various physiological conditions, including ionic strength and temperature, showed that ligands bound to the AuNP surface become less conformationally mobile with an increase in ionic strength or decreasing temperature. This exploration of ligand dynamics provides insight into designing nanoparticles tailored to specific biological applications.

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来源期刊
ACS Nanoscience Au
ACS Nanoscience Au 材料科学、纳米科学-
CiteScore
4.20
自引率
0.00%
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0
期刊介绍: ACS Nanoscience Au is an open access journal that publishes original fundamental and applied research on nanoscience and nanotechnology research at the interfaces of chemistry biology medicine materials science physics and engineering.The journal publishes short letters comprehensive articles reviews and perspectives on all aspects of nanoscience and nanotechnology:synthesis assembly characterization theory modeling and simulation of nanostructures nanomaterials and nanoscale devicesdesign fabrication and applications of organic inorganic polymer hybrid and biological nanostructuresexperimental and theoretical studies of nanoscale chemical physical and biological phenomenamethods and tools for nanoscience and nanotechnologyself- and directed-assemblyzero- one- and two-dimensional materialsnanostructures and nano-engineered devices with advanced performancenanobiotechnologynanomedicine and nanotoxicologyACS Nanoscience Au also publishes original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials engineering physics bioscience and chemistry into important applications of nanomaterials.
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