Selective α-Synuclein PET Radiotracer Development- Characterization

Ziel/Aim The deposition of α-synuclein fibrils (α-syn) is a major feature that unites a group of neurodegenerative diseases collectively known as the synucleinopathies. Presently, the in vivo detection of this biomarker is not possible due to lack of suitable radiotracers. Scientists from academics and industry are interested to develop radiotracers for the early diagnosis of α-synucleinopathies. Disarylbisthiazoles (DABTAs) based ligands have been showing high affinity towards α-syn and excellent selectivity over tau and Aβ aggregates. The aim of this work is characterization of the radiotracers within competition binding assays, autoradiography and pharmacokinetics (PK) study to confirm their high binding affinity and optimized pharmacokinetics and utilize them as a promising α-syn PET tracer.