{"title":"植物源性选择性生物活性皂苷和单宁:多靶点机制和多种生物活性综述","authors":"Dudday Venkata Vyshnavi, Sunkara Sivananda Swaroop, Akkiraju Sudheer, Somasekhar Reddy Kanala, Ramavath Muralidhar Naik, Onamala Varalakshmi","doi":"10.5530/pres.15.4.066","DOIUrl":null,"url":null,"abstract":"Pharmacognosy Research,2023,15,4,623-635.DOI:10.5530/pres.15.4.066Published:October 2023Type:Review ArticleAuthors:Dudday Venkata Vyshnavi, Sunkara Sivananda Swaroop, Akkiraju Sudheer, Somasekhar Reddy Kanala, Ramavath Muralidhar Naik, and Onamala Varalakshmi Author(s) affiliations:Dudday Venkata Vyshnavi1, Sunkara Sivananda Swaroop1, Akkiraju Sudheer1,*, Somasekhar Reddy Kanala1, Ramavath Muralidhar Naik2, Onamala Varalakshmi1 1Department of Pharmacology, Raghavendra Institute of Pharmaceutical Education and Research (RIPER)-Autonomous, Chiyyedu, Anantapuram, Andhra Pradesh, INDIA. 2Department of Pharmaceutics, Raghavendra Institute of Pharmaceutical Education and Research (RIPER)-Autonomous, Chiyyedu, Anantapuram, Andhra Pradesh, INDIA. Abstract:An extensive variety of ailments have been treated using medicinal herbs for ages. Recent research has revealed that many of these plants possess multiple therapeutic activities, rendering them interesting candidates for the creation of novel medicines. This review examines the current state of knowledge regarding the multi targeted activities of medicinal plants, including their potential for treating multiple diseases like anti-inflammatory, anti-microbial, anti-hyperglycaemic and anti-cancer activities, their ability to modulate multiple pathways, enzymes, genes and proteins. Finally, the review highlights the potential of naturally derived substances from plant material, for the development of multitargeted drugs and suggests strategies for further research. The multi-target activities will be thoroughly explored in this review of ginsenosides, platycodon D, dioscin, soyasaponins and aescin were chosen as saponins, whereas methyl gallate, chebulinic acid, tannic acid, theaflavin and punicalagins were chosen as tannins. This overview gives a brief history of the isolated natural compounds, their structures, multi-target activity, and their suggested mechanisms of action. 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Plant-Derived Selected Bioactive Saponins and Tannins: An Overview of their Multi-Target Mechanisms and Diverse Biological Activities
Pharmacognosy Research,2023,15,4,623-635.DOI:10.5530/pres.15.4.066Published:October 2023Type:Review ArticleAuthors:Dudday Venkata Vyshnavi, Sunkara Sivananda Swaroop, Akkiraju Sudheer, Somasekhar Reddy Kanala, Ramavath Muralidhar Naik, and Onamala Varalakshmi Author(s) affiliations:Dudday Venkata Vyshnavi1, Sunkara Sivananda Swaroop1, Akkiraju Sudheer1,*, Somasekhar Reddy Kanala1, Ramavath Muralidhar Naik2, Onamala Varalakshmi1 1Department of Pharmacology, Raghavendra Institute of Pharmaceutical Education and Research (RIPER)-Autonomous, Chiyyedu, Anantapuram, Andhra Pradesh, INDIA. 2Department of Pharmaceutics, Raghavendra Institute of Pharmaceutical Education and Research (RIPER)-Autonomous, Chiyyedu, Anantapuram, Andhra Pradesh, INDIA. Abstract:An extensive variety of ailments have been treated using medicinal herbs for ages. Recent research has revealed that many of these plants possess multiple therapeutic activities, rendering them interesting candidates for the creation of novel medicines. This review examines the current state of knowledge regarding the multi targeted activities of medicinal plants, including their potential for treating multiple diseases like anti-inflammatory, anti-microbial, anti-hyperglycaemic and anti-cancer activities, their ability to modulate multiple pathways, enzymes, genes and proteins. Finally, the review highlights the potential of naturally derived substances from plant material, for the development of multitargeted drugs and suggests strategies for further research. The multi-target activities will be thoroughly explored in this review of ginsenosides, platycodon D, dioscin, soyasaponins and aescin were chosen as saponins, whereas methyl gallate, chebulinic acid, tannic acid, theaflavin and punicalagins were chosen as tannins. This overview gives a brief history of the isolated natural compounds, their structures, multi-target activity, and their suggested mechanisms of action. Keywords:Bioactive compounds, Biological activities, Medicinal plants, Multi targets, saponins, TanninsView:PDF (711.79 KB)
期刊介绍：
Pharmacognosy Research [ISSN: Print -0976-4836, Online - 0974-8490] [http://www.phcogres.com], Quarterly a publication of Phcog.Net is published by Wolters Kluwer - Medknow Publications. It provides peer-reviewed original research articles from the field of Natural Products. The journal serves an international audience of scientists and researchers in a variety of research and academia by quickly disseminating research findings related to Medicinal Plants and Natural Products. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submissions of original contributions in all areas of pharmacognosy are welcome.
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