Isabeli Joaquim Contel, Pedro Pol Ximenes, Fernando Carmona Dinau, Fernanda Barthelson Carvalho de Moura, Giovanna Gati de Souza, Iolanda Simões Braga, Isadora Fernanda Pelaquim, Rafael Torres, Noeme Sousa Rocha
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Clinicopathological and immunohistochemical features of insulinoma in an adult mixed breed dog
Canine insulinoma is a common non-specific neoplasm with high metastasizing ability. Its epidemiology, diagnosis, and treatment are well described. However, its long-term prognosis is considered poor. We report a rare case of insulinoma in a small-size, mixed-breed adult dog, which presented with a circling walk, seizures, weakness, depressed mental state, and hypoglycemia. Glucose continuous rate infusion, diazepam, and phenobarbital were initiated to stabilize the glycemia and control the convulsion. Blood tests, fine needle aspiration cytology, ultrasound and radiological tests, and histology and immunohistochemical analysis confirmed the diagnosis of insulinoma, emphasizing the relevance of considering it as a differential diagnosis for small canine breeds and younger animals. Further, dogs can be regarded as an experimental animal model for human insulinoma research as they share characteristics.
期刊介绍:
The Brazilian Journal of Veterinary Pathology is the official electronic periodical of the Brazilian Association of Veterinary Pathology. The purpose of the BJVP is to publish original full papers, short communications, case reports, letters, reviews (by invited experts) and abstracts of scientific meetings. The preferable subjects is natural and experimental pathology. All the articles are submitted to scientific reviewers.