计算病理学在低her2乳腺癌鉴别中的应用:机遇与挑战

Q2 Medicine Journal of Pathology Informatics Pub Date : 2023-11-04 DOI:10.1016/j.jpi.2023.100343

Marie Brevet , Zaibo Li , Anil Parwani

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引用次数: 0

摘要

在过去的20年里，病理学家已经习惯于根据HER2免疫组化报告乳腺癌的HER2状态为阳性或阴性。然而，如今临床迫切需要采用三层方法来解释HER2免疫组化，这种方法也可以识别归类为HER2低的肿瘤。满足这种对更精细程度的区分的需求可能具有挑战性，在本文中，我们考虑了整合计算方法的潜力，以支持病理学家实现准确和可重复的HER2 IHC评分，并概述了一些涉及的实用性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Computational pathology in the identification of HER2-low breast cancer: Opportunities and challenges

For the past 2 decades, pathologists have been accustomed to reporting the HER2 status of breast cancer as either positive or negative, based on HER2 IHC. Today, however, there is a clinical imperative to employ a 3-tier approach to interpreting HER2 IHC that can also identify tumours categorised as HER2-low. Meeting this need for a finer degree of discrimination may be challenging, and in this article, we consider the potential for the integration of computational approaches to support pathologists in achieving accurate and reproducible HER2 IHC scoring as well as outlining some of the practicalities involved.

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来源期刊

Journal of Pathology Informatics Medicine-Pathology and Forensic Medicine

CiteScore

3.70

自引率

0.00%

发文量

审稿时长

18 weeks

期刊介绍： The Journal of Pathology Informatics (JPI) is an open access peer-reviewed journal dedicated to the advancement of pathology informatics. This is the official journal of the Association for Pathology Informatics (API). The journal aims to publish broadly about pathology informatics and freely disseminate all articles worldwide. This journal is of interest to pathologists, informaticians, academics, researchers, health IT specialists, information officers, IT staff, vendors, and anyone with an interest in informatics. We encourage submissions from anyone with an interest in the field of pathology informatics. We publish all types of papers related to pathology informatics including original research articles, technical notes, reviews, viewpoints, commentaries, editorials, symposia, meeting abstracts, book reviews, and correspondence to the editors. All submissions are subject to rigorous peer review by the well-regarded editorial board and by expert referees in appropriate specialties.