通过校准的自动血栓图确定暴露于劳力低压减压压力下的人的凝血特征

IF 0.9 Q4 HEMATOLOGY Hemato Pub Date : 2023-10-01 DOI:10.3390/hemato4040024
Leigh A. Madden, Rebecca V. Vince, Victoria C. Edwards, Vivienne M. Lee, Desmond M. Connolly
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引用次数: 0

摘要

人类对减压应激的凝血反应尚未得到充分的研究。在这里,我们对暴露于减压应激的健康志愿者的样本使用校准的自动血栓图(CAT)来研究实时凝血酶的产生。为了诱导减压应激,15名明显健康的男性(年龄20-50岁)在呼吸100%氧气的情况下,连续两次上升到25000英尺,分别持续60分钟(第一次上升)和90分钟(第二次上升)。在暴露前(T0)、第二次上升后(T8)和24小时(T24)采集柠檬酸血液样本。使用凝血镜etm获得凝血酶生成曲线。测定参数为滞后时间(lag)、峰值时间(TTP)、凝血酶峰值(peak)、内源性凝血酶电位(ETP)和流速指数(VEL)。在15名受试者中,12名具有有效的凝血特征。TTP与ETP差异无统计学意义。然而,从T0到T8, VEL显著增加(p = 0.025),从T8到T24 (p = 0.043)。从T0到T8 (p = 0.069)和从T8到T24 (p = 0.098)也观察到峰值总体增加的非显著趋势。PEAK与VEL存在相关性。综上所述,这两个参数表明,在低压应激后,总体上向更促凝的方向转变。
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Coagulation Profiles in Humans Exposed to Exertional Hypobaric Decompression Stress Determined by Calibrated Automated Thrombogram
The blood coagulation response to decompression stress in humans has yet to be fully investigated. Here we utilised calibrated automated thrombogram (CAT) on samples from healthy volunteers exposed to decompression stress to investigate real-time thrombin generation. To induce decompression stress, fifteen apparently healthy males (age 20–50 yr) were exposed to two consecutive ascents to 25,000 ft for 60 min (1st ascent) and then 90 min (2nd ascent) while breathing 100% oxygen. Citrated blood samples were taken prior to exposure (T0), following the 2nd ascent (T8) and at 24 h (T24). Thrombin generation curves were obtained using ThrombinoscopeTM. Parameters determined were lag time (LAG), time to peak (TTP), peak thrombin (PEAK), endogenous thrombin potential (ETP) and velocity index (VEL). Of the 15 subjects, 12 had validated coagulation profiles. TTP and ETP showed no significant differences. However, there was a significant increase in VEL from T0 to T8 (p = 0.025) and from T8 to T24 (p = 0.043). A non-significant trend of an overall increase in PEAK was also observed from T0 to T8 (p = 0.069) and from T8 to T24 (p = 0.098). PEAK and VEL were found to be correlated. Taken together, these two parameters suggest an overall shift towards a more procoagulant profile following hypobaric stress.
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11 weeks
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