Xiao-Bao Wu, Jun-Xiu Shi, Yi-Ming Ou, Hua-Jie Jiang, Yi-Jun Fang, Qi-Ming Wang, Quan Gao, Jie Yu
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Sequential enantioselective Ugi-4CR/post-Ugi transformation strategy: a precise construction of structurally diverse azaspiro polycyclic scaffolds
A privileged strategy has been developed for the precise construction of enantioenriched azaspiro polycyclic scaffolds. Structurally diverse azaspiro polycycles bearing multiple contiguous stereocenters are obtained with excellent results (up to 99:1 e.r., >95:5 d.r.) via sequential enantioselective four-component Ugi reactions/post-Ugi transformations with substrates containing prerequisite functional groups in the presence of anionic stereogenic-at-cobalt(III) complexes.
期刊介绍：
Science China Chemistry, co-sponsored by the Chinese Academy of Sciences and the National Natural Science Foundation of China and published by Science China Press, publishes high-quality original research in both basic and applied chemistry. Indexed by Science Citation Index, it is a premier academic journal in the field.
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Highlights. Brief summaries and scholarly comments on recent research achievements in any field of chemistry.
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Reviews. In-depth summaries of representative results and achievements of the past 5–10 years in selected topics based on or closely related to the research expertise of the authors, providing a thorough assessment of the significance, current status, and future research directions of the field.
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