蛋白酶体在限制与蛋白质积累相关的细胞应激中的作用

IF 2.3 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Israel Journal of Chemistry Pub Date : 2023-11-07 DOI:10.1002/ijch.202300120
Kate A. Kragness, Darci J. Trader
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引用次数: 0

摘要

蛋白酶体由多个亚基组成,这些亚基催化蛋白质降解以维持细胞内稳态。蛋白酶体通过两种不同的途径靶向蛋白质底物。泛素依赖途径需要用泛素标签标记蛋白质,以指示蛋白酶体的26S异构体降解。通过这一途径的蛋白质降解随着年龄的增长而下降。泛素非依赖性途径利用20S蛋白酶体异构体。它可以降解错误折叠和内在无序的蛋白质,以减少细胞压力。由于蛋白酶体的活性和表达降低,年龄相关的蛋白质积累和聚集可能发生。蛋白质积累导致细胞压力增加,从而导致疾病进展。提高蛋白酶体活性可以作为消除和防止蛋白质积累的解决方案。研究表明,蛋白酶体作为一种治疗实体的价值,以减轻细胞应激。这一观点探讨了蛋白酶体活性与由年龄相关的错误折叠蛋白积累引起的细胞应激之间的联系。
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The Role of the Proteasome in Limiting Cellular Stress Associated with Protein Accumulation
Abstract The proteasome is comprised of multiple subunits that catalyze the degradation of proteins to maintain cellular homeostasis. The proteasome targets protein substrates by two different pathways. The ubiquitin‐dependent pathway requires proteins to be labeled with a ubiquitin tag to signal for degradation by the 26S isoform of the proteasome. Protein degradation through this pathway declines during age progression. The ubiquitin‐independent pathway utilizes the 20S proteasome isoform. It can degrade misfolded and intrinsically disordered proteins to decrease cellular stress. Age‐related protein accumulation and aggregation can occur due to the decreased activity and expression of the proteasome. Protein accumulation causes increased cellular stress which can contribute to disease progression. Increasing proteasome activity could serve as a solution to eliminating and preventing protein accumulation. Studies have shown the value of the proteasome as a therapeutic entity to mitigate cellular stress. This perspective explores the link between proteasome activity and cellular stress caused by age‐related misfolded protein accumulation.
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来源期刊
Israel Journal of Chemistry
Israel Journal of Chemistry 化学-化学综合
CiteScore
6.20
自引率
0.00%
发文量
62
审稿时长
6-12 weeks
期刊介绍: The fledgling State of Israel began to publish its scientific activity in 1951 under the general heading of Bulletin of the Research Council of Israel, which quickly split into sections to accommodate various fields in the growing academic community. In 1963, the Bulletin ceased publication and independent journals were born, with Section A becoming the new Israel Journal of Chemistry. The Israel Journal of Chemistry is the official journal of the Israel Chemical Society. Effective from Volume 50 (2010) it is published by Wiley-VCH. The Israel Journal of Chemistry is an international and peer-reviewed publication forum for Special Issues on timely research topics in all fields of chemistry: from biochemistry through organic and inorganic chemistry to polymer, physical and theoretical chemistry, including all interdisciplinary topics. Each topical issue is edited by one or several Guest Editors and primarily contains invited Review articles. Communications and Full Papers may be published occasionally, if they fit with the quality standards of the journal. The publication language is English and the journal is published twelve times a year.
期刊最新文献
Cover Picture: (Isr. J. Chem. 8-9/2024) Special Issue on RNA-Based Catalysts that Revolutionized the Discovery of Bioactive Peptides Hexagonal and Trigonal Quasiperiodic Tilings Breaking the Degeneracy of Sense Codons – How Far Can We Go? Cover Picture: (Isr. J. Chem. 6-7/2024)
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