肝脏营养补充剂升糖指数的估算及其在肝脏营养中的重要性

Rachana Bhoite, Shobana Shanmugam, Varalakshmi Lalithya Pratti, Vinita Satyavrat, Gayathri Rajagopal, Ranjit Mohan Anjana, Viswanathan Mohan
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摘要

全球慢性肝病(CLD)发病率的增加表明饮食和生活方式改变的必要性。据报道,低血糖指数(GI)饮食对控制肝功能障碍引起的糖尿病有重要作用。国际标准组织(ISO)对健康人群中食物GI的测定进行了标准化。本研究旨在评估一种高蛋白、能量密集的肝脏营养补充剂的GI值。这项交叉随机对照研究随机分配了15名参与者,让他们食用27.5克葡萄糖(一水葡萄糖)或77克营养补充剂(相当于25克可用碳水化合物)作为参考食物;在3天的洗脱期后切换到另一只手臂。禁食过夜后,于补充食物或参考食物进食后15、30、45和60分钟采集血样。GI是根据营养补充剂引起的血糖反应下的增量面积与同一参与者消耗27.5克葡萄糖(一水葡萄糖)后反应的百分比计算的,使用标准公式。营养补充剂的平均GI值为11.4±2.4。与参考食物相比,食用这种营养补充剂后,餐后所有时间点的血糖水平都降低了。肝脏营养补充剂测试的GI值较低,血糖反应相对较慢,持续时间较长。因此,它可以用于CLD患者预防与CLD相关的代谢并发症,改善健康结果和生活质量。
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Estimation Of Glycemic Index Of Liver Nutritional Supplement And Its Importance In Liver Nutrition
A global increase in incidence of chronic liver disease (CLD) indicated the necessity of dietary and lifestyle modification. Low glycemic index (GI) diet was reported to have a significant role in controlling diabetes caused by liver dysfunction. The International Standards Organisation (ISO) has standardized the determination of GI of a food in healthy individuals. This study aimed to estimate GI value of a high protein, energy dense liver nutritional supplement. This cross-over randomized controlled study randomly allotted 15 participants to consume either reference food 27.5 gm glucose (glucose monohydrate) or 77 gm nutritional supplement (equivalent to 25 gm of available carbohydrates); switching to another arm was done after 3 days wash-out period. After overnight fast, blood samples were collected at 15, 30, 45 and 60 minutes post-consumption of s upplement or reference food. The GI was calculated from the incremental area under the blood glucose response elicited by the nutritional supplement as a percentage of the response after consumption of 27.5 gm of glucose (glucose monohydrate) by the same participant using a standard formula. Mean GI of the nutritional supplementwas estimated as 11.4 ± 2.4.With the consumption of this nutritional supplement, the blood glucose levels were reduced at all postprandial time points, compared to the reference food. The liver nutritional supplement tested has a low GI, and comparatively slower and more sustained blood glucose response. Therefore, it can be used in patients with CLD to prevent CLD-associated metabolic complications and improve health outcomes and quality of life.
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