孕期补充大铁和锌对婴儿出生后免疫反应和营养状况的影响:一项前瞻性干预研究

Helmizar Helmizar, Sri Rahma Sari, Utami Ariyasra, Andani Eka Putra
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摘要

背景:Dadih是一种印度尼西亚传统的发酵水牛奶,其生产和消费与4-10个月婴儿的分泌免疫球蛋白A (sIgA)水平和营养状况有关。目的:本研究旨在评价孕妇连续6个月补充叶酸和锌对粪便的影响。材料与方法:采用前瞻性随机对照试验方法,在2个地区对138名6个月的孕妇进行前瞻性随机对照试验,随机分为对照组、大钠组、大钠与锌联合组。然后,在6个月的时间里,分别对孕妇进行分组补充,每周6次。对婴儿进行人体测量和粪便sIgA测定。结果:母亲在妊娠期间分别补充大豆油、大豆油和锌以及正常饮食的婴儿营养状况患病率分别为发育迟缓10%、体重不足5.0%和消瘦5.0%;在未添加任何补充剂的孕妇组(对照组)中,22.5%的婴儿发育迟缓,20.0%的婴儿体重不足,5.0%的婴儿消瘦。8月龄及以上婴儿发育迟缓比例有下降趋势,分别为28.57%、31.25%和11.76%。他们的母亲补充了所有组。结论:大黛和锌有改善新生儿营养状况的潜力。此外,建议孕妇补充这两种类型,以减少发育迟缓的患病率。食用适量的豆豉中含有潜在的益生菌,可以帮助母亲和婴儿吸收营养物质,提高免疫力,对健康有益。为使婴儿达到最佳生长发育,应在他们两岁以下之前进行加速和生长。
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Immune Response and Nutritional Status of Infants’ Birth after Supplementation with Dadih and Zinc during Pregnancy: A Prospective Intervention Study
BACKGROUND: Dadih is an Indonesian traditional fermented buffalo milk produced and consumed by the secretory immunoglobulin A (sIgA) level and nutritional status of infants aged 4–10 months. AIM: This study aims to assess the effect of dadih and zinc supplementation given to pregnant mothers for 6 months on fecal. MATERIALS AND METHODS: A prospective randomized controlled trial was conducted in two districts on 138 pregnant mothers for 6 months, randomly assigned into three groups, namely, control, dadih, combination of dadih and zinc groups. Then, the combination of groups was supplemented to expecting mothers, respectively, 6 times a week during 6 months. Anthropometric measurement and fecal sIgA of infants were assessed. RESULTS: The prevalence of nutritional status of infants who mothers were supplemented during pregnancy with dadih, dadih and zinc, and, normal diet, respectively, are 10% stunting, 5.0% underweight, and 5.0% wasting infants; and 22.5% stunted, 20.0% underweight, and 5.0% wasting infants were found in expecting mothers supplemented with it and without any supplementation (control group). The percentage of stunting in 8 months and older infants tended to reduce: 28.57%, 31.25%, and 11.76%. Their mothers were supplemented with all groups. CONCLUSION: Dadih and zinc are potential for improving nutritional status of the newborn. In addition, the two types of supplementation are recommended to pregnant mothers, to reduce the prevalence of stunting. Potential probiotic contained in Dadih which consumed in adequate amounts can help the absorption of nutrients and increase immunity of mothers and infants amounts confer a health benefit. Acceleration and growth of infants to achieve optimal growth and development should be carried out before they are under two years old.
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期刊介绍: Open Access Macedonian Journal of Medical Sciences (OAMJMS) [formerly known as Macedonian Journal of Medical Sciences] is a top-tier open access medical science journal published by the ID Design 2012/DOOEL Skopje, Rajko Zhinzifov No 48, 1000 Skopje, Republic of Macedonia. OAMJMS is an international, modern, general medical journal covering all areas in the medical sciences, from basic studies to large clinical trials and cost-effectiveness analyses. We publish mostly human studies that substantially enhance our understanding of disease epidemiology, etiology, and physiology; the development of prognostic and diagnostic technologies; trials that test the efficacy of specific interventions and those that compare different treatments; and systematic reviews. We aim to promote translation of basic research into clinical investigation, and of clinical evidence into practice. We publish occasional studies in animal models when they report outstanding research findings that are highly clinically relevant. Our audience is the international medical community as well as educators, policy makers, patient advocacy groups, and interested members of the public around the world. OAMJMS is published quarterly online version. The Open Access Macedonian Journal of Medical Sciences (OAMJMS) publishes Medical Informatics, Basic Science, Clinical Science, Case Report, Brief Communication, Public Health, Public Policy, and Review Article from all fields of medicine and related fields. This journal also publishes, continuously or occasionally, the bibliographies of the members of the Society, medical history, medical publications, thesis abstracts, book reviews, reports on meetings, i­n­formation on future meetings, important events and dates, and various headings which contribute to the development of the corresponding scientific field.
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