维生素D水平与糖尿病:年龄、性别和身体质量指数的研究

Enver Çiftel, Serpil Çiftel, Ramazan Dayanan, Hasan Atlı
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摘要

目的:身体质量指数(BMI)与维生素D水平的相关性在当代医学研究中引起了相当大的关注。维生素D是一种必需的脂溶性微量营养素,对骨骼健康、免疫系统功能和其他各种生理功能有重要影响。维生素D的生物利用度可能受到肥胖的影响,这可能导致体重指数升高的人缺乏维生素D。这项在单一中心进行的回顾性研究的目的是在680人的队列中检查BMI和糖尿病(DM)与维生素D血清水平之间的潜在关系,其中包括511名女性和169名男性。方法:本研究采用的方法是全面审查来自单一机构的医疗记录,以收集BMI和血液25-羟基维生素D [25(OH)D]水平的相关信息。参与者根据他们的身体质量指数类别被分为四组,包括正常体重、超重、肥胖和病态肥胖。采用统计学方法探讨BMI、糖尿病(DM)、年龄与25(OH)D水平的关系。此外,还进行了多变量回归分析,以解释年龄和性别等潜在的混杂变量。结果:本研究纳入680人样本,其中女性511人(75.1%),平均年龄41(±12)岁;男性169人(24.9%),平均年龄38(±13)岁。女性体内的维生素D含量为14±7纳克/毫升,而男性体内的维生素D含量为16.6±7纳克/毫升。研究发现,女性和男性在维生素D水平上存在统计学上的显著差异(p<0.001)。研究结果表明,在所有个体中,维生素D水平与年龄之间没有显著的相关性(p=0.258)。然而,维生素D水平与BMI之间存在显著的相关性(p=0.002, R2=0.0141)。肥胖组的维生素D水平为14±7 ng/mL,非肥胖组的维生素D水平为16±7 ng/mL。统计分析显示,肥胖组的维生素D水平明显低于非肥胖组(p=0.012)。在比较糖尿病和非糖尿病个体之间的维生素D水平时,发现非糖尿病组的平均维生素D水平为13.8±6.3 ng/mL,糖尿病组的平均维生素D水平为16.6±7.6 ng/mL。统计分析显示,糖尿病组维生素D水平显著高于糖尿病组(p=0.012)。结论:我们的研究结果表明,低维生素D水平和肥胖之间存在潜在的联系,而糖尿病、年龄和性别等因素似乎对这种联系没有显著影响。
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Vitamin D Levels and Diabetes Mellitus: A Study on Age, Sex, and Body Mass Index
Objective: The correlation between Body Mass Index (BMI) and vitamin D levels has garnered considerable attention in contemporary medical investigations. Vitamin D, an essential fat-soluble micronutrient, significantly influences bone health, immune system functionality, and various other physiological functions. The bioavailability of vitamin D may be affected by adiposity, which might result in possible deficits in persons with elevated body mass indices. The objective of this retrospective study conducted at a single center was to examine the potential relationship between BMI and diabetes mellitus (DM) with vitamin D serum levels in a cohort of 680 individuals, comprising 511 females and 169 males. Methods: The present study utilized a methodology in which medical records from a single facility were comprehensively reviewed to collect relevant information on BMI and blood 25-hydroxyvitamin D [25(OH)D] levels. The participants were classified into four distinct groups based on their BMI categories, which included normal weight, overweight, obese, and morbidly obese. Statistical methods were employed to investigate the relationship between BMI, diabetes mellitus (DM), age, and 25-hydroxyvitamin D (25(OH)D) levels. Furthermore, multivariate regression analysis was conducted to account for potential confounding variables such as age and gender. Results: The study included a sample of 680 individuals, comprising 511 women (75.1%) with an average age of 41 (±12) and 169 men (24.9%) with an average age of 38 (±13). Vitamin D levels in women were found to be 14±7 ng/mL, while in men, the levels measured at 16.6±7 ng/mL. The study identified a statistically significant difference in vitamin D levels between women and men (p<0.001). The study's findings indicate that there was no significant correlation between vitamin D levels and age among all individuals (p=0.258). However, a significant albeit weak correlation was observed between vitamin D levels and BMI (p=0.002, R2=0.0141). The vitamin D levels of the obese group were measured to be 14±7 ng/mL, while the non-obese group had levels of 16±7 ng/mL. Statistical analysis revealed that vitamin D levels in the obese group were significantly lower compared to the non-obese group (p=0.012). When comparing vitamin D levels between individuals with and without diabetes mellitus (DM), it was observed that the mean vitamin D level was 13.8±6.3 ng/mL in the non-DM group and 16.6±7.6 ng/mL in the DM group. Statistical analysis revealed that vitamin D levels were significantly higher in the DM group (p=0.012). Conclusion: Our study's findings suggest a potential connection between low vitamin D levels and obesity, while factors such as diabetes, age, and gender do not seem to significantly impact this association.
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