中性粒细胞胞外陷阱(NETS)在牙周病中的潜在作用——扫描电镜(SEM)研究

IF 0.7 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY AIMS Molecular Science Pub Date : 2023-01-01 DOI:10.3934/molsci.2023014

Shreya Shetty, Sampat Kumar Srigiri, Karunakar Shetty

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引用次数: 0

摘要

& lt; abstract> & lt; sec>& lt; title> Background< / title>口腔生物膜是牙周病变的主要病因。中性粒细胞是对抗生物膜中病原体的第一道防线。它们运作的机制之一是中性粒细胞胞外陷阱(NETs)，这是一种新的防御机制。本研究旨在探讨它们在牙周病中的作用。& lt; / sec> & lt; sec>& lt; title> Methodology< / title>经机构伦理委员会批准，在牙周瓣手术中收集了10例牙周炎患者的牙龈(活检)样本，并在扫描电子显微镜(SEM)下进行了处理和检查。& lt; / sec> & lt; sec>& lt; title> Results< / title>< >扫描电镜检查显示，切除的牙龈组织显示出复杂的网状网络。& lt; / sec> & lt; sec>& lt; title> Conclusion< / title>net可能是防御牙周感染的一种手段，尽管需要进一步的研究来了解其作用的确切性质。& lt; / sec> & lt; / abstract>

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The potential role of neutrophil extracellular traps (NETS) in periodontal disease—A scanning electron microscopy (SEM) study

Background

Oral biofilms are the major etiological agents of periodontal pathologies. Neutrophils are the first line of defense in fighting the pathogens in the biofilm. One of the mechanisms by which they operate is neutrophil extracellular traps (NETs), which are a novel mechanism of defense in the presence of pathogenic plaque. The present study was carried out to investigate their role in periodontal disease.

Methodology

Following institutional ethical committee approval, ten gingival (biopsy) samples from individuals with periodontitis were collected during periodontal flap surgery and processed and examined under scanning electron microscope (SEM).

Results

SEM examination revealed that the excised gingival tissues displayed an intricate meshwork of NETs.

Conclusion

NETs may be one of the means of defense against periodontal infections, although further research is necessary to understand the exact nature of their role.

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来源期刊

AIMS Molecular Science BIOCHEMISTRY & MOLECULAR BIOLOGY-

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5 weeks