{"title":"美多巴联合普拉克索治疗帕金森病患者的疗效评价","authors":"Jianhua Liu, Chuanqi Wang, Yu Tan","doi":"10.26689/cnr.v1i2.5306","DOIUrl":null,"url":null,"abstract":"Objective: To analyze the clinical efficacy of Madopar combined with pramipexole in the treatment of Parkinson’s disease. Methods: This study was conducted from January 2021 to January 2023. This study involved 80 patients who were divided into two groups using a computerized randomization. The control group received pramipexole and the experimental group received both madopar and pramipexole. The treatment outcomes of these two groups were compared and analyzed. Results: The efficacy of the treatment received in the experimental group was 95.00%, which was higher than that of the control group (77.50%), whereas the total adverse reaction rate of the experimental group was 12.50%, which was lower than that of the control group, 35.00%; the difference was significant (P < 0.05). There was no difference in the levels of tumor necrosis factor α (TNF-α), interleukin 6 (IL-6), C-reactive protein (CRP), miR-124, miR-137, and Unified Parkinson’s Disease Rating Scale (UPDRS) total score (UPDRS Ⅱ, UPDRS Ⅲ, and UPDRS Ⅳ scores) between the control group and the experimental group (P > 0.05). After treatment, these indicators were significantly improved in the experimental group compared to the control group. Conclusion: Madopar combined with pramipexole in the treatment of Parkinson’s is both effective and safe. It delays the progression of the disease and has broad application prospects.","PeriodicalId":87465,"journal":{"name":"Clinical neuroscience research","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effect Evaluation of Madopar Combined with Pramipexole in the Treatment of Parkinson’s Patients\",\"authors\":\"Jianhua Liu, Chuanqi Wang, Yu Tan\",\"doi\":\"10.26689/cnr.v1i2.5306\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective: To analyze the clinical efficacy of Madopar combined with pramipexole in the treatment of Parkinson’s disease. Methods: This study was conducted from January 2021 to January 2023. This study involved 80 patients who were divided into two groups using a computerized randomization. The control group received pramipexole and the experimental group received both madopar and pramipexole. The treatment outcomes of these two groups were compared and analyzed. Results: The efficacy of the treatment received in the experimental group was 95.00%, which was higher than that of the control group (77.50%), whereas the total adverse reaction rate of the experimental group was 12.50%, which was lower than that of the control group, 35.00%; the difference was significant (P < 0.05). There was no difference in the levels of tumor necrosis factor α (TNF-α), interleukin 6 (IL-6), C-reactive protein (CRP), miR-124, miR-137, and Unified Parkinson’s Disease Rating Scale (UPDRS) total score (UPDRS Ⅱ, UPDRS Ⅲ, and UPDRS Ⅳ scores) between the control group and the experimental group (P > 0.05). After treatment, these indicators were significantly improved in the experimental group compared to the control group. Conclusion: Madopar combined with pramipexole in the treatment of Parkinson’s is both effective and safe. It delays the progression of the disease and has broad application prospects.\",\"PeriodicalId\":87465,\"journal\":{\"name\":\"Clinical neuroscience research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-09-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical neuroscience research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.26689/cnr.v1i2.5306\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical neuroscience research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.26689/cnr.v1i2.5306","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Effect Evaluation of Madopar Combined with Pramipexole in the Treatment of Parkinson’s Patients
Objective: To analyze the clinical efficacy of Madopar combined with pramipexole in the treatment of Parkinson’s disease. Methods: This study was conducted from January 2021 to January 2023. This study involved 80 patients who were divided into two groups using a computerized randomization. The control group received pramipexole and the experimental group received both madopar and pramipexole. The treatment outcomes of these two groups were compared and analyzed. Results: The efficacy of the treatment received in the experimental group was 95.00%, which was higher than that of the control group (77.50%), whereas the total adverse reaction rate of the experimental group was 12.50%, which was lower than that of the control group, 35.00%; the difference was significant (P < 0.05). There was no difference in the levels of tumor necrosis factor α (TNF-α), interleukin 6 (IL-6), C-reactive protein (CRP), miR-124, miR-137, and Unified Parkinson’s Disease Rating Scale (UPDRS) total score (UPDRS Ⅱ, UPDRS Ⅲ, and UPDRS Ⅳ scores) between the control group and the experimental group (P > 0.05). After treatment, these indicators were significantly improved in the experimental group compared to the control group. Conclusion: Madopar combined with pramipexole in the treatment of Parkinson’s is both effective and safe. It delays the progression of the disease and has broad application prospects.