Fabrication, spectroscopic properties, antioxidant and antimicrobial activities of Chitosan-CaLi@Flumox nanocomposites

Abstract In the current study, we examined the impact of introducing Flumox into the chitosan/calcium lithium (Chitosan-CaLi) nanocomposite on its spectroscopic, thermal, and antimicrobial characteristics. The formation of the nanocomposites was achieved using the sol–gel method/polymerization, which was chosen for its cost-effectiveness and straightforward processing. The UV–Visible optical analysis shows an absorption peak at 290 nm across all samples. Both direct and indirect energy gap types are available where the indirect event exhibits a higher value than the direct transition. There is a noticeable decrease in both transition energies with the increase in Flumox content. The findings indicated that as the Flumox concentration increased, the Ic 50 value also increased, signifying a decrease in antioxidant capacity. The results from the obtained systems revealed that chitosan-CaLiO nanoparticles loaded with Flumox exhibited remarkable antimicrobial activity, particularly against Pseudomonas aeruginosa and Staphylococcus aureus, demonstrating the highest growth inhibition rate. However, in the case of Aspergillus niger and Candida albicans, the antimicrobial activity was comparatively lower.