{"title":"治疗急性髓系白血病的潜在靶点:参与内质网应激的XBP1","authors":"neslihan abacı","doi":"10.5505/tjo.2023.3968","DOIUrl":null,"url":null,"abstract":"Endoplasmic reticulum (ER) stress, which occurs as a result of the accumulation of misfolded or un-folded proteins, has been observed in many cancers. To re-establish the ER homeostasis, pathways of un-folded protein response (UPR) are activated. The effect of ER stress-activated UPR pathways on leuke-mogenesis has not been elucidated. In this study, we aimed to find out whether activated UPR pathways were involved in acute myeloid leukemia (AML)","PeriodicalId":42117,"journal":{"name":"Turk Onkoloji Dergisi-Turkish Journal of Oncology","volume":null,"pages":null},"PeriodicalIF":0.3000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A Potential Target for Treating Acute Myeloid Leukemia: XBP1 involved in Endoplasmic Reticulum Stress\",\"authors\":\"neslihan abacı\",\"doi\":\"10.5505/tjo.2023.3968\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Endoplasmic reticulum (ER) stress, which occurs as a result of the accumulation of misfolded or un-folded proteins, has been observed in many cancers. To re-establish the ER homeostasis, pathways of un-folded protein response (UPR) are activated. The effect of ER stress-activated UPR pathways on leuke-mogenesis has not been elucidated. In this study, we aimed to find out whether activated UPR pathways were involved in acute myeloid leukemia (AML)\",\"PeriodicalId\":42117,\"journal\":{\"name\":\"Turk Onkoloji Dergisi-Turkish Journal of Oncology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.3000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Turk Onkoloji Dergisi-Turkish Journal of Oncology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5505/tjo.2023.3968\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Turk Onkoloji Dergisi-Turkish Journal of Oncology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5505/tjo.2023.3968","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ONCOLOGY","Score":null,"Total":0}
A Potential Target for Treating Acute Myeloid Leukemia: XBP1 involved in Endoplasmic Reticulum Stress
Endoplasmic reticulum (ER) stress, which occurs as a result of the accumulation of misfolded or un-folded proteins, has been observed in many cancers. To re-establish the ER homeostasis, pathways of un-folded protein response (UPR) are activated. The effect of ER stress-activated UPR pathways on leuke-mogenesis has not been elucidated. In this study, we aimed to find out whether activated UPR pathways were involved in acute myeloid leukemia (AML)
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
