肺动脉高压右心超声心动图评价

Jonathan Kusner, Richard A. Krasuski
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摘要

肺动脉高压(PH)的特征是右心室(RV)后负荷增加,早期右心室收缩力急剧增加以维持右心室-动脉耦合。与左心室(LV)的组织生物学特性有关,右心室的收缩特性不同于左心室。当左心室适应PH值时,出现超声心动图征象,可以帮助识别PH值,并可以重新评估PH值的无创预后。许多这些指标可以从标准超声心动图视图中计算出来,而无需对扫描程序进行重大修改。本文将讨论PH的当代诊断,强调超声心动图在这一过程中的作用。我们将描述左室和右室之间的差异,包括左室在PH值中的适应性,以及这些因素如何影响超声心动图评估。最后,我们将讨论具体的超声心动图参数,并描述其在诊断和重新评估中的作用。对右心进行常规评估可以改善PH的无创风险分层,可能减少诊断延误,并最终可能影响该患者群体的重大且可能改变的疾病负担。
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Echocardiographic Evaluation of the Right Heart in Pulmonary Hypertension
Pulmonary hypertension (PH) is characterized by increased right ventricular (RV) afterload, which is accommodated early by dramatic increases in RV contractility to maintain right ventriculoarterial coupling. Related to its tissue biology, characteristics of RV contractility differ from those of the left ventricle (LV). As the RV undergoes adaptation in PH, echocardiographic signs emerge which can help identify PH and can be reassessed to noninvasively prognosticate outcomes in PH. Many of these indices can be calculated from standard echocardiographic views without significant modification to scanning procedures. This review will discuss contemporary diagnosis of PH, highlighting the role of echocardiography in this process. We will describe the differences between the LV and RV, including adaptations of the RV in PH, and how these factors impact echocardiographic assessment. We will conclude with a discussion of specific echocardiographic parameters and describe their role in diagnosis and reassessment. Routine assessment of the right heart improves noninvasive risk stratification in PH, may reduce delays in diagnosis, and ultimately may impact the significant and potentially modifiable disease burden in this patient population.
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