多囊卵巢综合征血清催乳素代谢相关性:对孟加拉国840例患者的回顾性分析

Q3 Medicine Endocrine and Metabolic Science Pub Date : 2023-11-10 DOI:10.1016/j.endmts.2023.100153

A.B.M. Kamrul-Hasan , Fatema Tuz Zahura Aalpona

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引用次数: 0

摘要

探讨催乳素对多囊卵巢综合征(PCOS)患者代谢的影响。这项回顾性横断面研究分析了2017-2022年期间在孟加拉国Mymensingh一家三级医院内分泌科门诊就诊的新诊断为多囊卵巢综合征的女性的数据。提取并分析临床、人体测量和实验室数据，包括口服葡萄糖耐量试验结果、血脂、总睾酮(TT)、促甲状腺激素(TSH)和催乳素的测量结果。排除高催乳素(≥100 ng/mL)的病例。840例[中位年龄21.5(18.0-25.7)岁]纳入最终分析;17.1%为高泌乳素血症。血清催乳素与年龄(rs = - 0.153)、体重指数(rs = - 0.172)、腰围(rs = - 0.193)、甘油三酯(rs = - 0.174)、TT (rs = - 0.133)、代谢综合征(rs = - 0.073)呈显著负相关(P < 0.05)，与TSH呈正相关(rs = 0.090)。多元回归分析显示，在校正年龄和BMI后，催乳素与空腹血糖(FPG)呈负相关，与TSH呈正相关。在多囊卵巢综合征患者中，血清催乳素水平与某些代谢危险因素(如FPG)呈负相关。

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Metabolic association of serum prolactin in polycystic ovary syndrome: A retrospective analysis of 840 patients in Bangladesh

Aims

To explore the metabolic influence of prolactin in subjects with polycystic ovary syndrome (PCOS).

Methods

This retrospective cross-sectional study analyzed data of women newly diagnosed with PCOS attending the Endocrinology outpatient department of a tertiary hospital in Mymensingh, Bangladesh, during 2017–2022. Clinical, anthropometric, and laboratory data, including results of oral glucose tolerance test, measurements of serum lipids, total testosterone (TT), thyroid-stimulating hormone (TSH), and prolactin, were extracted and analyzed. Cases of high prolactin (≥100 ng/mL) were excluded.

Results

840 cases [median age 21.5 (18.0–25.7) years] were considered for final analysis; 17.1 % had hyperprolactinemia. Serum prolactin had significant negative correlations (P < 0.05) with age (r_s = − 0.153), body mass index (r_s = − 0.172), waist circumference (r_s = − 0.193), triglyceride (r_s = − 0.174), and TT (r_s = − 0.133) levels, and the presence of metabolic syndrome (r_s = − 0.073) and positive correlations with TSH (r_s = 0.090). In multiple regression analysis, prolactin was inversely associated with fasting plasma glucose (FPG) and positively associated with TSH after correcting for age and BMI.