Valentina Živković, Tatjana Cvetković, Biljana Radovanović Dinić, Vladimir Jurišić
{"title":"系统性红斑狼疮血液学参数、抗体和细胞因子与疾病活动性的相关性:一项横断面研究","authors":"Valentina Živković, Tatjana Cvetković, Biljana Radovanović Dinić, Vladimir Jurišić","doi":"10.1186/s43166-023-00222-9","DOIUrl":null,"url":null,"abstract":"Abstract Background The aim of the study was to investigate the association of neutrophil-to-lymphocyte (NLR) and platelet-to-lymphocyte ratios (PLR) with standard inflammation parameters, including erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), complement component C3, anti-double-stranded deoxyribonucleic acid (anti-dsDNA), anti-nucleosome and anti-C1q antibodies, and serum and urinary monocyte-chemoattractant protein-1 (MCP-1) with disease activity in patients with systemic lupus erythematosus (SLE). Results This study included 160 patients (145 female and 15 male patients), hospitalized at the Rheumatology Department. A positive correlation between NLR and ESR ( p < 0.01), anti-dsDNA antibodies ( p < 0.05), and PLR ( p < 0.001) was obtained, with a negative correlation with C3 ( p < 0.005). PLR shows a positive correlation with ESR ( p < 0.001), CRP ( p < 0.005), anti-dsDNA antibodies ( p < 0.001), anti-nucleosome antibodies ( p < 0.05), and urine MCP-1 ( p < 0.05), with a negative correlation with C3 ( p < 0.005). Univariate analysis showed that all the examined laboratory parameters were independent predictors of disease activity ( p < 0.001), while the method of standard multiple regression analysis revealed the most significant ESR and serum MCP-1 ( p < 0.05). Conclusions NLR and PLR, as inexpensive and accessible biomarkers, can help in routine clinical practice for the estimation of disease activity in SLE patients.","PeriodicalId":31002,"journal":{"name":"Egyptian Rheumatology and Rehabilitation","volume":"12 11","pages":"0"},"PeriodicalIF":0.8000,"publicationDate":"2023-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Correlation of hematological parameters, antibodies and cytokines with disease activity in systemic lupus erythematosus: a cross-sectional study\",\"authors\":\"Valentina Živković, Tatjana Cvetković, Biljana Radovanović Dinić, Vladimir Jurišić\",\"doi\":\"10.1186/s43166-023-00222-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Abstract Background The aim of the study was to investigate the association of neutrophil-to-lymphocyte (NLR) and platelet-to-lymphocyte ratios (PLR) with standard inflammation parameters, including erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), complement component C3, anti-double-stranded deoxyribonucleic acid (anti-dsDNA), anti-nucleosome and anti-C1q antibodies, and serum and urinary monocyte-chemoattractant protein-1 (MCP-1) with disease activity in patients with systemic lupus erythematosus (SLE). Results This study included 160 patients (145 female and 15 male patients), hospitalized at the Rheumatology Department. A positive correlation between NLR and ESR ( p < 0.01), anti-dsDNA antibodies ( p < 0.05), and PLR ( p < 0.001) was obtained, with a negative correlation with C3 ( p < 0.005). PLR shows a positive correlation with ESR ( p < 0.001), CRP ( p < 0.005), anti-dsDNA antibodies ( p < 0.001), anti-nucleosome antibodies ( p < 0.05), and urine MCP-1 ( p < 0.05), with a negative correlation with C3 ( p < 0.005). Univariate analysis showed that all the examined laboratory parameters were independent predictors of disease activity ( p < 0.001), while the method of standard multiple regression analysis revealed the most significant ESR and serum MCP-1 ( p < 0.05). Conclusions NLR and PLR, as inexpensive and accessible biomarkers, can help in routine clinical practice for the estimation of disease activity in SLE patients.\",\"PeriodicalId\":31002,\"journal\":{\"name\":\"Egyptian Rheumatology and Rehabilitation\",\"volume\":\"12 11\",\"pages\":\"0\"},\"PeriodicalIF\":0.8000,\"publicationDate\":\"2023-11-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Egyptian Rheumatology and Rehabilitation\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1186/s43166-023-00222-9\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"RHEUMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Egyptian Rheumatology and Rehabilitation","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1186/s43166-023-00222-9","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"RHEUMATOLOGY","Score":null,"Total":0}
Correlation of hematological parameters, antibodies and cytokines with disease activity in systemic lupus erythematosus: a cross-sectional study
Abstract Background The aim of the study was to investigate the association of neutrophil-to-lymphocyte (NLR) and platelet-to-lymphocyte ratios (PLR) with standard inflammation parameters, including erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), complement component C3, anti-double-stranded deoxyribonucleic acid (anti-dsDNA), anti-nucleosome and anti-C1q antibodies, and serum and urinary monocyte-chemoattractant protein-1 (MCP-1) with disease activity in patients with systemic lupus erythematosus (SLE). Results This study included 160 patients (145 female and 15 male patients), hospitalized at the Rheumatology Department. A positive correlation between NLR and ESR ( p < 0.01), anti-dsDNA antibodies ( p < 0.05), and PLR ( p < 0.001) was obtained, with a negative correlation with C3 ( p < 0.005). PLR shows a positive correlation with ESR ( p < 0.001), CRP ( p < 0.005), anti-dsDNA antibodies ( p < 0.001), anti-nucleosome antibodies ( p < 0.05), and urine MCP-1 ( p < 0.05), with a negative correlation with C3 ( p < 0.005). Univariate analysis showed that all the examined laboratory parameters were independent predictors of disease activity ( p < 0.001), while the method of standard multiple regression analysis revealed the most significant ESR and serum MCP-1 ( p < 0.05). Conclusions NLR and PLR, as inexpensive and accessible biomarkers, can help in routine clinical practice for the estimation of disease activity in SLE patients.