尿足霉素作为高血压肾病早期诊断的生物标志物的评估

Q4 Biochemistry, Genetics and Molecular Biology Ukrainian Biochemical Journal Pub Date : 2023-11-06 DOI:10.15407/ubj95.05.031
I. Kostovska, K. Tosheska-Trajkovska, D. Labudovic, S. Cekovska, O. Kostovski,, G. Spasovski
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引用次数: 0

摘要

慢性高血压相关肾损伤被称为高血压肾病(HN)。在该病的发病过程中足细胞损伤可导致唾液糖蛋白足alyxin释放到尿液中,因此足alyxin可能有助于HN的早期诊断。本研究的目的是研究HN患者尿足紫红素水平与临床和生化参数之间的关系,并评估尿足紫红素作为HN早期标志物的诊断效用。114名参与者被纳入这项横断面研究,包括30名健康对照和84名临床证实的慢性高血压(CH)患者。对血样进行了生化测试。分别用免疫比浊法和分光光度法测定尿微量白蛋白和肌酐水平;ELISA法测定尿足alyxin水平。根据尿微量白蛋白/肌酐比值(UM/CR)和慢性肾脏疾病(CKD)分期将所有CH患者分为亚组。结果显示,与健康对照组相比,尿足alyxin水平在UM/CR和CKD分期亚组中均显著升高。尿足霉素水平随CKD分期逐渐升高,特别是在IV期和V期,并且与UM/CR比相比,尿足霉素在HN早期检测中的敏感性更高。提示尿足霉素可作为慢性高血压患者高血压肾病早期诊断的重要、敏感指标。关键词:肌酐,诊断标志物,高血压肾病,微量白蛋白,足霉霉素,尿
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Assessment of urinary podocalyxin as a biomarker of early diagnosis of hypertensive nephropathy
Chronically high blood pressure-related kidney injury is known as hypertensive nephropathy (HN). Podocyte damage in the pathogenesis of this disease can result in the release of the sialoglycoprotein podocalyxin into the urine, so podocalyxin may be useful in the early diagnosis of HN. The purpose of the study was to examine the relationships between urine podocalyxin level and clinical and biochemical parameters in individuals with HN and to assess the diagnostic utility of urinary podocalyxin as an early marker of HN. Participants (114 individuals) were enrolled in this cross-sectional study, including 30 healthy controls and 84 patients with clinically proven chronic hypertension (CH). Biochemical tests were performed on the blood samples. Urinary microalbumin and creatinine levels were measured using immunoturbidimetric and spectrophotometric methods, respectively; urinary podocalyxin level was estimated with ELISA. All CH patients were classified into subgroups according to urine microalbumin/creatinine ratio (UM/CR) and the stage of chronic kidney disease (CKD). The results obtained showed that urinary podocalyxin level was significantly increased in both UM/CR and CKD staging subgroups compared with the healthy control group. A gradual increase in urinary podocalyxin level with CKD stage, especially in IV and V stages, and the higher sensitivi­ty of urinary podocalyxin as compared to UM/CR ratio in early detection of HN was demonstrated. It was concluded that urinary podocalyxin may be an important and highly sensitive marker for early diagnosis of hypertensive nephropathy in patients with chronic hypertension. Keywords: creatinine, diagnostic marker, hypertensive nephropathy, microalbumin, podocalyxin, urine
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来源期刊
Ukrainian Biochemical Journal
Ukrainian Biochemical Journal Biochemistry, Genetics and Molecular Biology-Biochemistry
CiteScore
1.20
自引率
0.00%
发文量
37
审稿时长
16 weeks
期刊介绍: The Ukrainian Biochemical Journal publishes original research papers, reviews and brief notes; papers on research methods and techniques; articles on the history of biochemistry, its development and prominent figures; discussion articles; book reviews; chronicles; etc. The journal scope includes not only biochemistry but also related sciences, such as cellular and molecular biology, bioorganic chemistry, biophysics, pharmacology, genetics, and medicine (medical biochemistry et al.) – insofar as the studies use biochemical methods and discuss biochemical findings.
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