COMPARATIVE EVALUATION OF C-REACTIVE PROTEIN LEVELS AMONG PERI-IMPLANT HEALTH AND DISEASE CONDITIONS

Background: Peri-implant disease pathogenesis results in production of pro-inflammatory mediators, among which C-reactive protein (CRP) is one of the acute phase reactants. The aim of the study was to comparative CRP levels among peri-implant health and disease conditions. Materials and Methods: The present study was carried out in the Department of Implantology, Saveetha Dental College and Hospitals, Chennai, India. A total of 40 patients with peri-implant health (n=10), peri-mucositis (n=10), early peri-implantitis (n=10) and advanced peri-implantitis (n=10) were enrolled. Unstimulated salivary samples were collected and subjected to latex agglutination assay for CRP analysis. CRP levels were then correlated with peri-implant health and diseases. Results: CRP level in peri-implant health, peri-implant mucositis, early peri-implantitis and advanced peri-implantitis were 0.18±0.04 mg/dl, 2.05±0.61 mg/dl, 4.14±1.82 mg/dl and 6.21±1.35 mg/dl respectively. There was a statistically significant difference in CRP levels between all the tested groups (ANOVA, p=0.03). Pearson correlation coefficient analysis revealed a strong positive correlation between CRP and peri-implant health status. Conclusion: CRP level was high among patients with peri-implantitis followed by peri-implant mucositis and peri-implant health. Also, CRP level increases with severity of peri-implant diseases and there exists a positive correlation between CRP level and peri-implant health status.