尼日利亚Nnamdi Azikiwe大学教学医院人类免疫缺陷病毒血清阳性孕妇的抗核抗体、抗β 2-糖蛋白-1和甲状腺过氧化物酶自身抗体水平评估

John Ekenedirichukwu Okwara, Joseph Eberendu Ahaneku, Charles Chinedum Onyenekwe, Gerald Okanandu Udigwe, Joseph Ifeanyichukwu Ikechebelu, Emmanuel Chidiebere Okwara, Nuratu Adejumoke Okwara, Salaam Mujeeb, Emeka Callistus Onyeka Izuchukwu
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引用次数: 0

摘要

背景:妊娠与生物化学改变有关,并可能因人类免疫缺陷病毒(HIV)感染而加重,可能影响妊娠结局。目的:本研究评估了一些可能影响hiv感染妇女妊娠结局的生化参数。患者、材料和方法:该研究涉及从Nnamdi Azikiwe大学教学医院产前诊所招募的136名接受高效抗逆转录病毒治疗(HAART)的艾滋病毒血清阳性孕妇和137名艾滋病毒血清阴性孕妇。采用酶联免疫吸附法检测抗核抗体(ANAs)、抗β 2-糖蛋白-1 (βGP1)和甲状腺过氧化物酶自身抗体(TPOab)。结果:HIV血清阳性受试者TPOab(104.9±51.06 IU/mL)显著升高(P >0.05),对照组(89.5±33.5 IU/mL)。实验组ANA和βGP1(0.89±0.31;(12.94±8.9),差异无统计学意义(P >0.05),与对照组(0.84±0.27;分别为10.37±9.6)。三个月间测定的生化参数无显著变化(P >0.05)。此外,各被试组不同APGAR评分的被试间测定的生化参数无显著差异。结论:HIV感染对HAART治疗下HIV妊娠患者TPOab水平有影响,但对ANA、bGP1、APGAR评分无影响。
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Assessment of Antinuclear Antibodies, Anti-Beta 2-Glycoprotein-1, and Thyroid Peroxidase Autoantibody Levels in Human Immunodeficiency Virus Sero-positive Pregnant Women at Nnamdi Azikiwe University Teaching Hospital, Nnewi Nigeria
Abstract Background: Pregnancy is associated with biochemical alterations and may be compounded by human immunodeficiency virus (HIV) infection potentially affecting pregnancy outcome. Aims: This study evaluated some biochemical parameters that could possibly affect pregnancy outcomes in HIV-infected women. Patients, Materials and Methods: The study involved 136 HIV sero-positive on highly active antiretroviral therapy (HAART) and 137 HIV sero-negative pregnant women, recruited from the Antenatal Clinic of Nnamdi Azikiwe University Teaching Hospital, Nnewi. Antinuclear antibodies (ANAs), anti-beta 2-glycoprotein-1 (βGP1), and thyroid peroxidase autoantibody (TPOab) were analysed using the enzyme-linked immunosorbent assay methods. Results: TPOab in HIV sero-positive subjects (104.9 ± 51.06 IU/mL) was significantly higher ( P > 0.05) compared with controls (89.5 ± 33.5 IU/mL). ANA and βGP1 in test group (0.89 ± 0.31; 12.94 ± 8.9, respectively) did not change significantly ( P > 0.05) compared with the controls (0.84 ± 0.27; 10.37 ± 9.6, respectively). There were no significant changes in measured biochemical parameters between trimesters ( P > 0.05). Furthermore, there were no significant differences in measured biochemical parameters between subjects with different APGAR scores in all subject groups. Conclusion: HIV infection affected TPOab level but had no impact on ANA, bGP1, and APGAR score in HIV pregnancy under HAART.
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来源期刊
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0.00%
发文量
65
审稿时长
20 weeks
期刊介绍: The Nigerian Journal of Medicine publishes articles on socio-economic, political and legal matters related to medical practice; conference and workshop reports and medical news.
期刊最新文献
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