血液透析患者冠状动脉血运重建术的现状

Hiroyuki Nakajima, Yusuke Watanabe
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摘要

与经皮冠状动脉介入治疗(PCI)相比,冠状动脉旁路移植术(CABG)对血液透析(HD)患者的长期临床结果有利,因为PCI具有较低的短期死亡率,但后期血运重建风险较高。因此,在目前的临床实践中,冠脉搭桥对HD患者非常重要。在HD患者中,动静脉瘘的存在可能会降低同侧胸内动脉(ITA)的流量并诱发血流偷取,而伴随的微血管疾病(MVD)即使在CABG后也会引起心肌缺血和不可逆的心肌损伤。使用同侧ITA作为游离移植物或对侧ITA作为左前降支移植物都是合理的选择。MVD使术前评估复杂化,并可能恶化HD患者的临床结果。移植物的选择和冠状动脉和体循环的MVD是相互影响的未来问题。
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Current Issues in Coronary Revascularization for Hemodialysis Patients
Coronary artery bypass grafting (CABG) is advantageous for long-term clinical outcomes compared to percutaneous coronary intervention (PCI) in hemodialysis (HD) patients, as PCI has a lower short-term mortality but higher late revascularization risk. Therefore, CABG is very important for HD patients in current clinical practice. In HD patients, the presence of an arteriovenous fistula may lower the flow capacity of the ipsilateral internal thoracic artery (ITA) and induce flow steal, and concomitant microvascular disease (MVD) can cause myocardial ischemia and irreversible myocardial damage even after CABG. The use of the ipsilateral ITA as a free graft or the contralateral ITA as a graft to the left anterior descending artery can be reasonable options. MVD complicates the preoperative evaluation and could worsen clinical outcomes in HD patients. Graft selection and MVD in coronary and systemic circulation are mutually influential future concerns.
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