Platelet-rich plasma (PRP): history of the platelets� concentrates and current applications in medicine

Over the years, regenerative medicine has been improved thanks to new therapies and new innovative clinical protocols. The purpose of this work was to evaluate the efficacy of Platelet-rich Plasma by retracing the history of the evolution of the preparation technique, enhancing the role of platelets in tissue healing, as well as its use in various sectors of medicine. At the same time, through a critical review of recent innovations in the field of bone regeneration, was paid attention to new clinical protocols obtained from second generation platelet concentrates.