沙特阿拉伯吉赞市耐多药结核病的患病率和危险因素

IF 0.2 Q4 RESPIRATORY SYSTEM Egyptian Journal of Chest Diseases and Tuberculosis Pub Date : 2023-01-01 DOI:10.4103/ecdt.ecdt_113_22
Wael Abdelfattah, Majid A Darraj, Abuobaida K Yassin, Heba M Shalaby
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引用次数: 0

摘要

背景耐药结核病(DR-TB)是一个全球性的挑战。正如世卫组织提供的年度全球结核病报告所述,由于耐多药结核病(MDR-TB)或耐利福平结核病的年死亡率和发病率很高,2021年全球范围内的流行率呈上升趋势。从2018年到2022年,结核病患者约为4000万人,其中包括150万耐药结核病患者。这项研究的目标是确定沙特阿拉伯吉赞市耐多药结核病的流行情况和危险因素。患者与方法对2019年1 - 4月在吉赞胸科医院诊断为肺结核的114例患者进行研究。收集了人口统计数据。所有肺结核患者均行蒙托试验、胸片、痰涂片和洛温斯坦-詹森培养。患者被分配到A组,103例(90.4%)患者,如果他们有结核分枝杆菌敏感的分离株,或B组,11例(9.7%)患者,如果他们有结核分枝杆菌耐药的分离株。结果观察到耐药结核总患病率为9.7%。耐多药结核分枝杆菌占7%,耐多药结核分枝杆菌占0.9%,耐利福平结核分枝杆菌占0.9%,耐乙胺丁醇结核分枝杆菌占0.9%。B组女性(54.5%)多于A组(26.2%)。未婚患者A组(60.2%)高于B组(29.3%)。合并症在耐药组有显著的价值(90.9%)。结论本研究表明,筛查和治疗耐药结核病对吉赞和沙特阿拉伯整个地区的结核病控制至关重要。
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Prevalence and risk factors of multidrug-resistant tuberculosis in Jazan, Saudi Arabia
Abstract Background Drug-resistant tuberculosis (DR-TB) is a global challenge. Owing to its high annual mortality and morbidity rates, as stated in the annual global TB reports provided by WHO, the prevalence of multidrug-resistant tuberculosis (MDR-TB) or rifampicin-resistant tuberculosis was shown to be increasing worldwide in 2021. Patients with tuberculosis from 2018 to 2022 represented ~40 million individuals, including 1.5 million with DR-TB. The study’s goal was to identify MDR-TB prevalence and risk factors in Jazan, Saudi Arabia. Patients and methods The research was done on 114 patients diagnosed with pulmonary TB in Jazan Chest Hospital from January to April, 2019. Demographic data were collected. Monteux test, chest radiograph, sputum smear, and Lowenstein–Jensen culture were performed for all patients with pulmonary TB. Patients were allocated in either group A, with 103 (90.4%) patients, if they had Mycobacterium tuberculosis -susceptible isolates, or in group B, with 11 (9.7%) patients, if they had M. tuberculosis -resistant isolates. Results The observed overall DR-TB prevalence was 9.7%. The proportion of MDR isolates was 7%, polyresistant isolate TB was 0.9%, rifampicin-resistant tuberculosis was 0.9%, and ethambutol-resistant TB was 0.9%. Females were more in group B (54.5%) than in group A (26.2%). Unmarried patients were higher in group A (60.2%) than in group B (29.3%). Comorbidities had significant values in the drug-resistant groups (90.9%). Conclusion The study showed that screening and treatment of DR-TB are crucial for the control of TB in Jazan and Saudi Arabia as a whole.
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发文量
46
审稿时长
22 weeks
期刊介绍: The journal will cover technical and clinical studies related to health, ethical and social issues in field of The Egyptian Journal of Chest Diseases and Tuberculosis aims to publish and inform readers and all chest physicians of the progress in medical research concerning all aspect of chest diseases. Publications include original articles review articles, editorials, case studies and reports which are relevant to chest diseases. The Journal also aims to highlight recent updates in chest medicine. . Articles with clinical interest and implications will be given preference.
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