新冠肺炎暴发后肺炎支原体肺炎流行病学及遗传特征分析

IF 0.2 4区 医学 Q4 INFECTIOUS DISEASES Journal of Pediatric infectious diseases Pub Date : 2023-11-06 DOI:10.1055/s-0043-1776043
Lin Li, Bing-han Wang, Wei Li
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引用次数: 0

摘要

摘要目的了解肺炎支原体肺炎(Mycoplasma pneumoniae pneumonia, MPP)是儿童社区获得性肺炎的重要组成部分,探讨新冠肺炎(COVID-19)暴发后肺炎支原体肺炎(Mycoplasma pneumoniae pneumonia, MPP)的流行病学和遗传学特征。方法收集2021年1月至2021年12月住院呼吸道感染患者咽拭子样本15538份。所有标本均采用实时逆转录聚合酶链反应(RT-PCR)检测。对阳性标本中肺炎支原体(MP) P1基因进行扩增和测序。结果2021年1月至2021年12月,本研究共对15538例急性呼吸道感染患儿进行实时RT-PCR检测,其中男生9056例,女生6482例。总体而言,469例(3.0%,469/15,538)MP检测呈阳性,其中男性266例(2.9%,266/9,056),女性203例(3.1%,203/6,482)(p = 0.48)。p < 0.05;1岁组、1 ~ 3岁组、3 ~ 5岁组、5 ~ 7岁组、7岁组分别为1.31%(85/ 6474)、1.87%(64/ 3423)、3.65%(95/ 2601)、8.02%(127/ 1583)、6.72%(98/ 1458)。24份MP阳性样品P1基因同源性分析显示,核苷酸序列一致性达91.2 ~ 99.3%。结论新冠肺炎疫情暴发后,5 ~ 7岁儿童MPP阳性检出率最高,中国杭州地区MPP基因型集中在P1亚型,即I型。
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Epidemiological and Genetic Characteristics of Mycoplasma pneumoniae Pneumonia after the Outbreak of COVID-19
Abstract Objective Mycoplasma pneumoniae pneumonia (MPP) accounts for a major part of community-acquired pneumonia in children, and we performed this study to investigate the epidemiological and genetic characteristics of MPP after the outbreak of COVID-19. Methods A total of 15,538 throat swab samples were collected from inpatients with respiratory tract infections from January 2021 to December 2021. All specimens were detected by real-time reverse transcriptase polymerase chain reaction (RT-PCR). The P1 gene of Mycoplasma pneumoniae (MP) in positive samples was amplified and sequenced. Results From January 2021 to December 2021, a total of 15,538 children with acute respiratory tract infection were tested by real-time RT-PCR in our study, including 9,056 boys and 6,482 girls. Overall, 469 (3.0%, 469/15,538) tested positive for MP, with 266 (2.9%, 266/9,056) males and 203 (3.1%, 203/6,482) females (p = 0.48). The positive rates of MP infection in < 1 year old, 1 to 3 years old, 3 to 5 years old, 5 to 7 years old, and >7 years old groups were 1.31% (85/6,474), 1.87% (64/3,423), 3.65% (95/2,601), 8.02% (127/1,583), and 6.72% (98/1,458), respectively. The homology analysis of the P1 gene of 24 MP positive samples showed that the nucleotide sequence consistency was up to 91.2 to 99.3%. Conclusion After the outbreak of COVID-19, positive detection rate was the highest from 5 to 7 years old among children with MPP, and the genotype of MP in Hangzhou, China area was focused on P1 subtype, type I.
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来源期刊
Journal of Pediatric infectious diseases
Journal of Pediatric infectious diseases Medicine-Pediatrics, Perinatology and Child Health
CiteScore
0.60
自引率
0.00%
发文量
50
期刊介绍: The Journal of Pediatric Infectious Diseases is a peer-reviewed medical journal publishing articles in the field of child infectious diseases. The journal provides an in-depth update on new subjects and current comprehensive coverage of the latest techniques used in diagnosis and treatment of childhood infectious diseases. The following articles will be considered for publication: editorials, original and review articles, rapid communications, letters to the editor and book reviews. The aim of the journal is to share and disseminate knowledge between all disciplines in the field of pediatric infectious diseases.
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