反刍动物反式脂肪酸对健康的影响,重点是2型糖尿病

IF 2.1 Q1 AGRICULTURE, DAIRY & ANIMAL SCIENCE Frontiers in animal science Pub Date : 2023-11-06 DOI:10.3389/fanim.2023.1278966
Yanqing Xu, Michael E. R. Dugan, Cletos Mapiye, Payam Vahmani
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引用次数: 0

摘要

最近发达国家政府对工业反式脂肪酸(TFA)的禁令使得反刍动物产品(如乳制品、牛肉和羊肉)中自然产生的TFA成为食品供应中TFA的唯一来源。工业TFA对健康有无可争议的不利影响,反刍动物TFA如反式异丙酸(TVA;trans - 11-18:1),瘤胃酸(RA;顺式9,trans11-18:2)和反式棕榈油酸(TPA;Trans9-16:1)与降低2型糖尿病等疾病的风险有关。本综述总结了反刍动物TFA对2型糖尿病相关代谢参数影响的观察性、动物和人类研究的结果,并提供了其生物合成、摄入量和影响其在反刍动物衍生食品中浓度的因素的最新知识。总的来说,观察性研究和少量动物研究表明,反刍动物TFA可能对2型糖尿病有保护作用,而在其他动物研究或人类临床试验中尚未观察到同样的益处。需要更多的临床和机理研究来更好地了解反刍动物TFA的异构体特异性作用。在此之前,应仔细重新考虑导致反刍动物奶和肉中这类脂肪酸含量增加的生产实践。
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Health effects of ruminant trans fatty acids with emphasis on type 2 diabetes
Recent government bans on industrial trans fatty acids (TFA) in developed countries has left naturally occurring TFA from ruminant products (e.g., dairy, beef, and lamb) as the sole source of TFA in the food supply. In contrast to industrial TFA, which have undisputed adverse health effects, ruminant TFA such as trans vaccenic acid (TVA; trans11-18:1), rumenic acid (RA; cis9, trans11-18:2) and trans palmitoleic acid (TPA; trans9-16:1) have been associated with reduced risk for some diseases such as type 2 diabetes. The present review summarizes the findings from observational, animal and human studies investigating the effects of ruminant TFA on metabolic parameters related to type 2 diabetes, and provides an update on the current knowledge of their biosynthesis, intake and factors affecting their concentrations in ruminant derived foods. Overall, observational studies and a small number of animal studies suggest that ruminant TFA may be protective against type 2 diabetes, whereas the same benefits have not been observed in other animal studies or in human clinical trials. Additional clinical and mechanistic studies are needed to better understand the isomer-specific effects of ruminant TFA. Until then, production practices resulting in increased levels of this group of fatty acids in ruminant milk and meat should be carefully reconsidered.
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CiteScore
2.30
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0.00%
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审稿时长
13 weeks
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