Ferroptosis as a biological Phase transition II: Chronotherapy of avascular and vascular tumor growth

The process of ferroptosis has become an alternative therapy to fight cancer. As a continuation of previous work, a non-autonomous model was developed for avascular and vascular tumor growth under periodic perturbations that simulate the application of a chronotherapeutically modulated treatment based on triggering the ferroptosis process. It was found that for critical amplitude and a perturbation frequency of twice the autonomous frequency in vascular growth, less complex and therefore less robust states are reached, and the tumor population decreases.