肾上腺中神经肽定位的免疫组织化学分析。

H Kondo
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引用次数: 129

摘要

免疫组织化学研究的最新进展彻底改变了我们对肾上腺的认识,发现许多神经肽存在于染色质细胞和肾上腺内神经元成分中。多肽和儿茶酚胺的共存是染色质细胞的一个恒定特征。在某些嗜铬细胞中也可见多种多肽的共存。这表明,就所含的生物活性物质而言,嗜铬细胞中存在几个亚群。传统的观点认为肾上腺内神经主要是支配嗜铬细胞的神经节前胆碱能神经,与此不同的是,肾上腺内神经是由含有各种不同神经肽的异质群体组成的。这些被认为有几个不同的起源。这些神经不仅支配嗜铬细胞,而且部分支配皮质细胞,并进一步与肾上腺内血管有关。基于免疫组织化学的发现,已经提出了肾上腺中神经肽的几种可能的作用过程。肾上腺应视为内分泌器官,不仅分泌儿茶酚胺,还分泌各种神经肽;它可能在维持身体内部环境方面发挥着比以前认为的更重要和更多样化的作用。
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Immunohistochemical analysis of the localization of neuropeptides in the adrenal gland.

Recent advances in immunohistochemical studies have revolutionalized our understanding of the adrenal gland with the discovery that many neuropeptides exist in the chromaffin cells and intraadrenal neuronal components. The coexistence of peptides and catecholamines is a constant feature of the chromaffin cells. The coexistene of multiple peptides is also seen in some chromaffin cells. This indicates that there are several subpopulations among the chromaffin cells in terms of bioactive substances contained. Diverging from the traditional view that intraadrenal nerves are predominantly preganglionic cholinergic ones innervating the chromaffin cells, the nerves are revealed to consist of heterogeneous populations containing various different neuropeptides. These are presumed to be of several different origins. The nerves innervate not only the chromaffin cells but partially the cortical cells, too, and are further associated with intraadrenal blood vessels. Several possible courses of action for the neuropeptides in the adrenal gland have been proposed based on immunohistochemical findings. The adrenal gland should be regarded as an endocrine organ, secreting not only catecholamines but also various neuropeptides; it likely plays more important and varied roles than previously believed for the maintainance of the internal environment of the body.

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