新型冠状病毒在环境中传播的数值模拟及敏感性分析

Maratus Sholihatul Azizah, Trisilowati Trisilowati, Nur Shofianah
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摘要

本文旨在建立一个涉及环境中病毒的新型COVID-19数学模型。在这个数学模型中,人类被分为五个亚群体:易感个体、暴露个体、感染个体、住院个体和治愈个体。此外,该模型还包含了环境中的病毒种群。模型中的感染是由于易感个体亚群与受感染个体和住院治疗之间的相互作用以及病毒在环境中的传播而发生的。根据动力学分析结果,该模型具有无病平衡点和地方病平衡点。无病平衡点总是存在的,当满足Routh-Hurwitz准则时,两个平衡点都是局部渐近稳定的。对影响基本繁殖数的模型参数进行模型敏感性分析,其中最敏感的参数为自然死亡率、招募率、病毒在环境中的传播率、病毒清除率、个人防护装备佩戴率,以及不影响基本繁殖数的参数为恢复种群的离开率。数值模拟的结果与分析一致,并且从模拟中可以得出,在具有较高敏感性指数的环境中,病毒传播率的增加(或减少)对基本繁殖数和感染群体数的影响比住院个体传播率的影响更显著。关键词:基本繁殖数,动态分析,疫情模型,局部稳定性分析,敏感性分析
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Numerical Simulation and Sensitivity Analysis of COVID-19 Transmission Involves Virus in the Environment
This paper is aimed to develop a new COVID-19 mathematical model involving viruses in the environment. In this mathematical model, the human population is divided into five subpopulations: susceptible, exposed, infected, hospitalized, and cured individuals. In addition, the model also contains the virus population in the environment. Infection in the model occurs due to interactions between susceptible individual subpopulations and infected individuals and hospitalizations, as well as the spread of the virus in the environment. Based on the results of dynamic analysis, this model has two equilibrium points, the disease-free and endemic equilibrium points. The disease-free equilibrium point always exists, and both equilibrium points are locally asymptotically stable if they meet the Routh-Hurwitz criteria. Model sensitivity analysis was carried out on model parameters that affect the basic reproduction number with the most sensitive parameters are the natural death rate, the recruitment rate, the transmission rate of the virus in the environment, the virus clearance rate, and the rate of wearing PPE (Personal Protective Equipment), as well as the parameter that does not affect the basic reproduction number that is the rate of leaving the recovered population. Numerical simulations performed show results in accordance with the analysis, also from the simulations can be concluded that the increase (or decrease) of the transmission rate of the virus in an environment that has a higher sensitivity index has more significant influences on the basic reproduction number and the number of infected population than the transmission rate of hospitalized individuals. Keywords: Basic Reproduction Number, Dynamics Analysis, Epidemic Models of COVID-19, Local Stability Analysis, Sensitivity Analysis.
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