{"title":"桔梗素D通过调节eif4e介导的RNA甲基组抑制非小细胞肺癌血管生成的血管模拟","authors":"Shuyu Zheng, Yanlin Xin, Jiamin Lin, Zejuan Xie, Keyu Cheng, Shanshan Wang, Wenli Lu, Hao Yang, Tianming Lu, Jun Li, Ruogu Qi, Yuanyuan Guo","doi":"10.1016/j.jpha.2023.10.003","DOIUrl":null,"url":null,"abstract":"• The m7G-lncRNAs were identified through whole transcriptome-seq of PD and RIP validation. • The anti-VM effect of PD on NSCLC was investigated both in vivo and in vitro. • The synergistic effect was found in combinational use of PD and eIF4E inhibitor on NSCLC via destabilization of EGFR.","PeriodicalId":16737,"journal":{"name":"Journal of Pharmaceutical Analysis","volume":"275 1","pages":"0"},"PeriodicalIF":6.1000,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Platycodin D inhibits angiogenic vascular mimicry in NSCLC by regulating the eIF4E-mediated RNA methylome\",\"authors\":\"Shuyu Zheng, Yanlin Xin, Jiamin Lin, Zejuan Xie, Keyu Cheng, Shanshan Wang, Wenli Lu, Hao Yang, Tianming Lu, Jun Li, Ruogu Qi, Yuanyuan Guo\",\"doi\":\"10.1016/j.jpha.2023.10.003\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"• The m7G-lncRNAs were identified through whole transcriptome-seq of PD and RIP validation. • The anti-VM effect of PD on NSCLC was investigated both in vivo and in vitro. • The synergistic effect was found in combinational use of PD and eIF4E inhibitor on NSCLC via destabilization of EGFR.\",\"PeriodicalId\":16737,\"journal\":{\"name\":\"Journal of Pharmaceutical Analysis\",\"volume\":\"275 1\",\"pages\":\"0\"},\"PeriodicalIF\":6.1000,\"publicationDate\":\"2023-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Pharmaceutical Analysis\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1016/j.jpha.2023.10.003\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Pharmaceutical Analysis","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/j.jpha.2023.10.003","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
Platycodin D inhibits angiogenic vascular mimicry in NSCLC by regulating the eIF4E-mediated RNA methylome
• The m7G-lncRNAs were identified through whole transcriptome-seq of PD and RIP validation. • The anti-VM effect of PD on NSCLC was investigated both in vivo and in vitro. • The synergistic effect was found in combinational use of PD and eIF4E inhibitor on NSCLC via destabilization of EGFR.
期刊介绍：
The Journal of Pharmaceutical Analysis (JPA), established in 2011, serves as the official publication of Xi'an Jiaotong University.
JPA is a monthly, peer-reviewed, open-access journal dedicated to disseminating noteworthy original research articles, review papers, short communications, news, research highlights, and editorials in the realm of Pharmacy Analysis. Encompassing a wide spectrum of topics, including Pharmaceutical Analysis, Analytical Techniques and Methods, Pharmacology, Metabolism, Drug Delivery, Cellular Imaging & Analysis, Natural Products, and Biosensing, JPA provides a comprehensive platform for scholarly discourse and innovation in the field.
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