阿片受体的二元性、异位调节和不同信号：未来的治疗潜力

IF 0.9 Q3 ANESTHESIOLOGY Revista Espanola de Anestesiologia y Reanimacion Pub Date : 2023-10-16 DOI:10.1016/j.redar.2022.06.009

A.M. González, A.G. Jubete

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引用次数: 0

摘要

阿片类药物仍然是治疗手术后急性疼痛和慢性癌症疼痛的首选药物。这些药物的过量使用在一些国家引发了 "阿片类药物危机"。在这种情况下，人们开始关注各种配体的治疗潜力，这些配体可作为正交结合位点的异位调节剂，调节药物的活性、亲和力、效力甚至疗效。

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Dualismo, modulación alostérica y señalización diferencial en los receptores opiáceos: futuro potencial terapéutico

Opioids are still the drugs of choice for the treatment of acute post-surgical pain and chronic cancer pain. Overprescribing of these drugs has given rise to an “opioid crisis” in some countries. In this context, attention has been drawn to the therapeutic potential of various ligands that act as allosteric modulators of orthosteric binding sites and modulate the drug's activity, affinity, potency, and even efficacy.

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