{"title":"糖尿病是痛风的危险因素和合并症","authors":"Larisa Rotaru, Liliana Groppa, Eugeniu Russu, Lia Chișlari, Cătălin Codreanu, Larisa Spinei, Oleg Arnaut, Cornelia Cornea","doi":"10.3897/folmed.65.e91075","DOIUrl":null,"url":null,"abstract":"Introduction : Metabolic disorders are a public health issue because of the complications they cause, but they are also a major risk factor for the onset of gout. Aim : The current study set out to demonstrate clinically how the clinical-paraclinical evaluation methodology had advanced as well as to assess comorbidity in gout patients using diabetes mellitus (DM). We also wanted to examine the pancreatic dysfunction in gout patients of different ages (by assessing the glucose and glycolated Hb analyses). Materials and methods : Two hundred gout patients (mean age, men 60±8.0 years, women 63±9.0 years) were included in a descriptive, cross-sectional study. The diagnosis of gout was made according to the classification criteria for gout according to ACR and EULAR 2015. The raw data were analyzed using SPSS v. 26.0. Results : In the study, type 2 diabetes mellitus (DM2) was encountered with a comparable frequency among both middle-aged and elderly patients (33.8% and 41.8%, respectively, p =0.26). In only 15% of cases, DM2 preceded the development of gout (in 3% with the beginning and 12% with late onset), while the developmental age of the DM2 prior to gout was comparable (50.9±2.8 years in age group 1 and 55.1±6.9 years in age group 2). We found that elderly people experience gout much more frequently (up to 41%) when DM2 is present. However, DM2 is not considered a predictor of gout. Conclusions : In gout patients under the age of 59 inclusive, the mean age at diabetes onset is significantly lower than the age (37.49.6 years) at which diabetes develops in the general population. Early onset of diabetes is associated with early development of gout.","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Diabetes mellitus as a risk factor and comorbidity in gout\",\"authors\":\"Larisa Rotaru, Liliana Groppa, Eugeniu Russu, Lia Chișlari, Cătălin Codreanu, Larisa Spinei, Oleg Arnaut, Cornelia Cornea\",\"doi\":\"10.3897/folmed.65.e91075\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Introduction : Metabolic disorders are a public health issue because of the complications they cause, but they are also a major risk factor for the onset of gout. Aim : The current study set out to demonstrate clinically how the clinical-paraclinical evaluation methodology had advanced as well as to assess comorbidity in gout patients using diabetes mellitus (DM). We also wanted to examine the pancreatic dysfunction in gout patients of different ages (by assessing the glucose and glycolated Hb analyses). Materials and methods : Two hundred gout patients (mean age, men 60±8.0 years, women 63±9.0 years) were included in a descriptive, cross-sectional study. The diagnosis of gout was made according to the classification criteria for gout according to ACR and EULAR 2015. The raw data were analyzed using SPSS v. 26.0. Results : In the study, type 2 diabetes mellitus (DM2) was encountered with a comparable frequency among both middle-aged and elderly patients (33.8% and 41.8%, respectively, p =0.26). In only 15% of cases, DM2 preceded the development of gout (in 3% with the beginning and 12% with late onset), while the developmental age of the DM2 prior to gout was comparable (50.9±2.8 years in age group 1 and 55.1±6.9 years in age group 2). We found that elderly people experience gout much more frequently (up to 41%) when DM2 is present. However, DM2 is not considered a predictor of gout. Conclusions : In gout patients under the age of 59 inclusive, the mean age at diabetes onset is significantly lower than the age (37.49.6 years) at which diabetes develops in the general population. Early onset of diabetes is associated with early development of gout.\",\"PeriodicalId\":12415,\"journal\":{\"name\":\"Folia medica\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-10-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Folia medica\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3897/folmed.65.e91075\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Dentistry\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Folia medica","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3897/folmed.65.e91075","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Dentistry","Score":null,"Total":0}
引用次数: 0
摘要
导言:代谢紊乱是一个公共卫生问题,因为它们引起的并发症,但它们也是痛风发作的主要危险因素。目的:目前的研究旨在临床证明临床-临床旁评价方法的发展,以及评估合并糖尿病的痛风患者的合并症。我们还想检查不同年龄的痛风患者的胰腺功能障碍(通过评估葡萄糖和糖化Hb分析)。材料和方法:200例痛风患者(平均年龄,男性60±8.0岁,女性63±9.0岁)纳入描述性横断面研究。根据ACR和EULAR 2015的痛风分类标准进行痛风诊断。原始数据采用SPSS v. 26.0进行分析。结果:在研究中,2型糖尿病(DM2)在中老年患者中发病率相当(分别为33.8%和41.8%,p =0.26)。在只有15%的病例中,DM2先于痛风的发展(3%为开始,12%为晚发),而DM2在痛风之前的发育年龄是相似的(年龄组1为50.9±2.8岁,年龄组2为55.1±6.9岁)。我们发现,当DM2存在时,老年人痛风的发生率更高(高达41%)。然而,DM2不被认为是痛风的预测因子。结论:在59岁以下的痛风患者中,糖尿病发病的平均年龄明显低于一般人群中糖尿病发病的年龄(37.49.6岁)。糖尿病的早期发病与痛风的早期发展有关。
Diabetes mellitus as a risk factor and comorbidity in gout
Introduction : Metabolic disorders are a public health issue because of the complications they cause, but they are also a major risk factor for the onset of gout. Aim : The current study set out to demonstrate clinically how the clinical-paraclinical evaluation methodology had advanced as well as to assess comorbidity in gout patients using diabetes mellitus (DM). We also wanted to examine the pancreatic dysfunction in gout patients of different ages (by assessing the glucose and glycolated Hb analyses). Materials and methods : Two hundred gout patients (mean age, men 60±8.0 years, women 63±9.0 years) were included in a descriptive, cross-sectional study. The diagnosis of gout was made according to the classification criteria for gout according to ACR and EULAR 2015. The raw data were analyzed using SPSS v. 26.0. Results : In the study, type 2 diabetes mellitus (DM2) was encountered with a comparable frequency among both middle-aged and elderly patients (33.8% and 41.8%, respectively, p =0.26). In only 15% of cases, DM2 preceded the development of gout (in 3% with the beginning and 12% with late onset), while the developmental age of the DM2 prior to gout was comparable (50.9±2.8 years in age group 1 and 55.1±6.9 years in age group 2). We found that elderly people experience gout much more frequently (up to 41%) when DM2 is present. However, DM2 is not considered a predictor of gout. Conclusions : In gout patients under the age of 59 inclusive, the mean age at diabetes onset is significantly lower than the age (37.49.6 years) at which diabetes develops in the general population. Early onset of diabetes is associated with early development of gout.