同种异体精子捐赠者沙眼衣原体筛查:是否有必要对每一项捐赠进行检测,还是定期检测就足够了?

N. De Munck, J. Sterckx, D. Brackman, E. Stoop, K. Wouters, H. Tournaye
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摘要

异体精子捐献沙眼衣原体筛查:每次捐献都要检测还是定期筛查就足够了?关于精子捐献者的筛选有一些指导方针。对于乙型肝炎、丙型肝炎和艾滋病毒,这些指南是明确的,但对于沙眼衣原体的建议则相反,非常不同。直到2021年6月30日,布鲁塞尔体外受精中心(比利时)对所有捐精者进行了3个月一次的沙眼原体筛查。鉴于精子捐赠中传播的理论风险,这种定期筛查受到了质疑。研究人员在2021年6月30日之前收集了精子捐赠,当时每次捐赠的尿液都没有检测沙眼原体。在1809个未经检测的捐精者中,从42个捐精者中随机抽取190个。这190名捐献的精子使用核酸检测(NAT)检测沙眼原体。在检测的190根精子吸管中,NAT后未检测到沙眼衣原体感染。这些结果表明,最初的定期检测方法似乎足够安全且具有成本效益,可以排除沙眼衣原体感染。因此,对未经检测的吸管进行事后检测以及在每次捐献时进行检测似乎都是不必要的。
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Screening naar Chlamydia trachomatis bij allogene spermadonoren: is het noodzakelijk om elke donatie te testen of volstaan periodieke tests?
Screening for Chlamydia trachomatis in allogeneic sperm donation: is it necessary to test every donation or is periodic screening sufficient? There are several guidelines regarding the screening of sperm donors. For hepatitis B and C and HIV, these guidelines are unambiguous, but the recommendations for Chlamydia trachomatis are, on the contrary, very heterogeneous. Until 30 June 2021, a 3-monthly screening for C. trachomatis was performed at Brussels IVF (Belgium) on all sperm donors. This periodic screening has been questioned given the theoretical risk for transmission in sperm donation. The researchers collected sperm donations before 30 June 2021, when urine was not tested for C. trachomatis at each donation. Of the 1,809 untested donations, 190 donations from 42 sperm donors were randomly selected. These 190 sperm donations were tested for C. trachomatis using a nucleic acid test (NAT). For the tested 190 sperm straws, no infection with C. trachomatis was detected after NAT. These results show that the initial method of periodic testing seems sufficiently safe and cost-efficient to exclude infections with C. trachomatis. Both post-hoc testing of untested straws as well as testing at each donation seem therefore unnecessary.
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