派姆单抗治疗头颈部鳞状细胞癌:临床病例和现实世界的实践

Yu. V. Alymov, I. S. Romanov, A. V. Ignatova
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摘要

复发性和转移性头颈部鳞状细胞癌是一种难以治疗的病理。标准化疗方案的中位总生存期不超过11个月。降低治疗效果的因素之一是严重不良事件的发生频率,在标准治疗方案中每2例患者中就有1例出现严重不良事件。此外,即使实现了显著的肿瘤消退,这种效果也是短暂的。免疫治疗药物的开发,即派姆单抗,有助于解决这些问题。临床试验和该药物的实际使用表明,在复发和转移性头颈部鳞状细胞癌的第一和第二治疗线中,派姆单抗可以实现持续的治疗反应,增加总生存期,并降低不良事件的频率。
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Pembrolizumab in treatment of head and neck squamous cell carcinoma: clinical cases and real-world practice
Recurrent and metastatic head and neck squamous cell carcinoma is a hard-to-treat pathology. median overall survival for standard chemotherapy regimens does not exceed 11 months. One of the factors decreasing treatment effectivenessis frequency of severe adverse events which are observed in every 2nd patient during standard therapy regimens. moreover, even if notable tumor regression is achieved, this effect is transient. Development of immunotherapy drugs, namely pembrolizumab, helps solve these problems. Clinical trials and real-world use of the drug show that in the 1st and 2nd therapy lines for recurrent and metastatic head and neck squamous cell carcinoma, pembrolizumab allows to achieve persistent treatment response, increase overall survival, and decrease the frequency of adverse events.
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