抗 NXP-2 抗体可及早改善皮肌炎患者的甲襞视网膜镜检查异常情况

IF 1.1 Q4 ALLERGY Journal of Cutaneous Immunology and Allergy Pub Date : 2023-10-13 DOI:10.1002/cia2.12334

Naoki Mugii PhD, Yasuhito Hamaguchi MD, PhD, Natsumi Fushida MD, Motoki Horii MD, PhD, Tasuku Kitano MD, Ko Fujii MD, Kaori Sawada MD, PhD, Kyosuke Oishi MD, PhD, Shintaro Maeda MD, PhD, Takashi Matsushita MD, PhD

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摘要

本研究旨在评估抗核基质蛋白2（NXP-2）抗体（Ab）皮肌炎患者甲襞视频毛细血管镜（NVC）检查结果的长期变化。四名抗核基质蛋白2（NXP-2）抗体患者在初次评估时均出现毛细血管不规则扩大和缩小以及出血。病情稳定后，不规则扩大的毛细血管和出血在平均 6 个月的观察期内消失。而抗 TIF1 Ab 患者则没有观察到这些早期改善。本研究结果表明，应使用肌炎特异性抗体信息来评估 NVC 结果的长期变化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Early improvement of nailfold videocapillaroscopy abnormalities in dermatomyositis patients with anti-NXP-2 antibody

This study aimed to evaluate long-term changes in nailfold videocapillaroscopy (NVC) findings in dermatomyositis patients with antinuclear matrix protein 2 (NXP-2) antibody (Ab). All four patients with anti-NXP-2 Ab presented irregularly enlarged and reduced capillaries and hemorrhages at the initial assessment. After disease stabilization, irregularly enlarged capillaries and hemorrhages disappeared within the mean observation period of 6 months. These early improvements were not observed in patients with anti-TIF1 Ab. The results of this study show that long-term changes in NVC findings should be assessed using myositis-specific Ab information.

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