哥本哈根妊娠丢失研究(COPL)中无细胞胎儿DNA的遗传评价:一项前瞻性队列研究

IF 4.3 4区医学 Q1 OBSTETRICS & GYNECOLOGY Obstetrical & Gynecological Survey Pub Date : 2023-06-01 DOI:10.1097/ogx.0000000000001163

Tanja Schlaikjær Hartwig, Louise Ambye, Jennifer R. Gruhn, Jesper Friis Petersen, Tine Wrønding, Letizia Amato, Andrew Chi-Ho Chan, Boyang Ji, Maiken Hemme Bro-Jørgensen, Lene Werge, Mette Marie Babiel Schmidt Petersen, Clara Brinkmann, Julie Birch Petersen, Morten Dunø, Iben Bache, Markus J. Herrgård, Finn Stener Jørgensen, Eva R. Hoffmann, Henriette Svarre Nielsen

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引用次数: 0

摘要

(摘自Lancet 2023; 401:762-771)自然流产发生率约为1 / 4;然而，诊断检查主要局限于复发性流产的妇女。缺乏对首次妊娠丢失的检查可能是由于新生儿非整倍体率高;然而，这忽略了整倍体妊娠丢失与未来丢失风险增加的关联。

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Cell-Free Fetal DNA for Genetic Evaluation in Copenhagen Pregnancy Loss Study (COPL): A Prospective Cohort Study

(Abstracted from Lancet 2023;401:762–771 Spontaneous pregnancy loss occurs in approximately 1 in 4 pregnancies; however, diagnostic workup is mostly restricted to women with recurrent pregnancy loss. The lack of workup on first pregnancy loss is likely a result of the high de novo fetal aneuploidy rate; however, this ignores the association of euploid pregnancy loss with an increased risk of future losses.

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来源期刊

Obstetrical & Gynecological Survey 医学-妇产科学

CiteScore

2.70

自引率

3.20%

发文量

245

审稿时长

>12 weeks

期刊介绍： Each monthly issue of Obstetrical & Gynecological Survey presents summaries of the most timely and clinically relevant research being published worldwide. These concise, easy-to-read summaries provide expert insight into how to apply the latest research to patient care. The accompanying editorial commentary puts the studies into perspective and supplies authoritative guidance. The result is a valuable, time-saving resource for busy clinicians.