用三维微流体辅助纺丝揭开生物材料墨水的分层图案:生物打印技术的范式转变

Sajad Mohammadi, Gianluca Cidonio
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引用次数: 0

摘要

几十年来,3D生物打印提供了一种革命性的方法,将活细胞和生物材料结合起来,设计出复杂但功能齐全的结构。然而,传统的3D生物打印平台缺乏对生物材料、细胞和最终生物物理特性的复杂梯度进行图案化以驱动组织形成和再生的能力。最近,3D微流控辅助生物打印(3DMB)作为一种新的混合方法兴起,用于制造生理相关组织,采用微流控芯片作为功能打印头,实现生物墨水的分层图案和对打印结构的微尺度结构的精确控制,从而实现多层组织的创建。本文综述了利用微流体辅助纺丝和新型生物3D打印技术在梯度生物材料图图化方面的最新进展。在此讨论人体组织的生理层次排列和生物材料在实现有序组装中的关键作用。最后,强调了微流体辅助技术与新型生物打印平台的集成,研究了组织再生和疾病建模的最新进展。
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Unravelling hierarchical patterning of biomaterial inks with 3D microfluidic-assisted spinning: a paradigm shift in bioprinting technologies
For decades, 3D bioprinting has offered a revolutionising approach to combine living cells and biomaterials to engineer complex, yet functional constructs. However, traditional 3D bioprinting platforms fall short of the ability to pattern complex gradients of biomaterials, cells, and ultimately bio-physical properties to drive tissue formation and regeneration. Recently, 3D microfluidic-assisted bioprinting (3DMB) has risen as a new hybrid approach for the fabrication of physiologically relevant tissues, adopting a microfluidic chip as functional printhead to achieve hierarchical patterning of bioinks and precise control over the microscale architecture of printed constructs, enabling the creation of multi-layered tissues. This review explores recent advancements in graded biomaterial patterning using microfluidic-assisted spinning and novel 3D bioprinting technologies. The physiological hierarchical arrangement of human tissues and the crucial role of biomaterials in achieving ordered assembly is hereby discussed. Lastly, the integration of microfluidic-assisted techniques with new bioprinting platforms is highlighted, examining the latest advancements in tissue regeneration and disease modelling.
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