Effect of nonsurgical periodontal therapy on serum lipid profile levels – A comparative study

Background: Regarding the high prevalence of hyperlipidemia, which is one of the major risk factors of cardiovascular disease and periodontitis, which is a known bacterial infection, classified as local chronic inflammation. Aim: The present study aimed to assess and correlate periodontal parameters with serum lipid profile levels at baseline and 45 days after nonsurgical periodontal therapy (NSPT). Results: It showed a statistically significant decrease in total cholesterol, low-density lipoproteins (LDL), very LDL and triglycerides, and a significant rise in high-density lipoproteins correlated with a significant reduction in the plaque index and gingival index, from baseline to 45 days after NSPT. Conclusion: It can be concluded that elevated serum lipids have a dysregulatory effect on the tissue response, which, in turn, affects the extent and progression of periodontitis, and in the presence of periodontitis, lipid metabolism will be affected through the systemic effect of cytokines.