{"title":"使用可解释的机器学习方法对中风诊断中的生物力学时间序列进行创新的可视化方法:一项概念验证研究","authors":"Kyriakos Apostolidis, Christos Kokkotis, Evangelos Karakasis, Evangeli Karampina, Serafeim Moustakidis, Dimitrios Menychtas, Georgios Giarmatzis, Dimitrios Tsiptsios, Konstantinos Vadikolias, Nikolaos Aggelousis","doi":"10.3390/info14100559","DOIUrl":null,"url":null,"abstract":"Stroke remains a predominant cause of mortality and disability worldwide. The endeavor to diagnose stroke through biomechanical time-series data coupled with Artificial Intelligence (AI) poses a formidable challenge, especially amidst constrained participant numbers. The challenge escalates when dealing with small datasets, a common scenario in preliminary medical research. While recent advances have ushered in few-shot learning algorithms adept at handling sparse data, this paper pioneers a distinctive methodology involving a visualization-centric approach to navigating the small-data challenge in diagnosing stroke survivors based on gait-analysis-derived biomechanical data. Employing Siamese neural networks (SNNs), our method transforms a biomechanical time series into visually intuitive images, facilitating a unique analytical lens. The kinematic data encapsulated comprise a spectrum of gait metrics, including movements of the ankle, knee, hip, and center of mass in three dimensions for both paretic and non-paretic legs. Following the visual transformation, the SNN serves as a potent feature extractor, mapping the data into a high-dimensional feature space conducive to classification. The extracted features are subsequently fed into various machine learning (ML) models like support vector machines (SVMs), Random Forest (RF), or neural networks (NN) for classification. In pursuit of heightened interpretability, a cornerstone in medical AI applications, we employ the Grad-CAM (Class Activation Map) tool to visually highlight the critical regions influencing the model’s decision. Our methodology, though exploratory, showcases a promising avenue for leveraging visualized biomechanical data in stroke diagnosis, achieving a perfect classification rate in our preliminary dataset. The visual inspection of generated images elucidates a clear separation of classes (100%), underscoring the potential of this visualization-driven approach in the realm of small data. This proof-of-concept study accentuates the novelty of visual data transformation in enhancing both interpretability and performance in stroke diagnosis using limited data, laying a robust foundation for future research in larger-scale evaluations.","PeriodicalId":38479,"journal":{"name":"Information (Switzerland)","volume":null,"pages":null},"PeriodicalIF":2.4000,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Innovative Visualization Approach for Biomechanical Time Series in Stroke Diagnosis Using Explainable Machine Learning Methods: A Proof-of-Concept Study\",\"authors\":\"Kyriakos Apostolidis, Christos Kokkotis, Evangelos Karakasis, Evangeli Karampina, Serafeim Moustakidis, Dimitrios Menychtas, Georgios Giarmatzis, Dimitrios Tsiptsios, Konstantinos Vadikolias, Nikolaos Aggelousis\",\"doi\":\"10.3390/info14100559\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Stroke remains a predominant cause of mortality and disability worldwide. The endeavor to diagnose stroke through biomechanical time-series data coupled with Artificial Intelligence (AI) poses a formidable challenge, especially amidst constrained participant numbers. The challenge escalates when dealing with small datasets, a common scenario in preliminary medical research. While recent advances have ushered in few-shot learning algorithms adept at handling sparse data, this paper pioneers a distinctive methodology involving a visualization-centric approach to navigating the small-data challenge in diagnosing stroke survivors based on gait-analysis-derived biomechanical data. Employing Siamese neural networks (SNNs), our method transforms a biomechanical time series into visually intuitive images, facilitating a unique analytical lens. The kinematic data encapsulated comprise a spectrum of gait metrics, including movements of the ankle, knee, hip, and center of mass in three dimensions for both paretic and non-paretic legs. Following the visual transformation, the SNN serves as a potent feature extractor, mapping the data into a high-dimensional feature space conducive to classification. The extracted features are subsequently fed into various machine learning (ML) models like support vector machines (SVMs), Random Forest (RF), or neural networks (NN) for classification. In pursuit of heightened interpretability, a cornerstone in medical AI applications, we employ the Grad-CAM (Class Activation Map) tool to visually highlight the critical regions influencing the model’s decision. Our methodology, though exploratory, showcases a promising avenue for leveraging visualized biomechanical data in stroke diagnosis, achieving a perfect classification rate in our preliminary dataset. The visual inspection of generated images elucidates a clear separation of classes (100%), underscoring the potential of this visualization-driven approach in the realm of small data. This proof-of-concept study accentuates the novelty of visual data transformation in enhancing both interpretability and performance in stroke diagnosis using limited data, laying a robust foundation for future research in larger-scale evaluations.\",\"PeriodicalId\":38479,\"journal\":{\"name\":\"Information (Switzerland)\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.4000,\"publicationDate\":\"2023-10-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Information (Switzerland)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3390/info14100559\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"COMPUTER SCIENCE, INFORMATION SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Information (Switzerland)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3390/info14100559","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"COMPUTER SCIENCE, INFORMATION SYSTEMS","Score":null,"Total":0}
Innovative Visualization Approach for Biomechanical Time Series in Stroke Diagnosis Using Explainable Machine Learning Methods: A Proof-of-Concept Study
Stroke remains a predominant cause of mortality and disability worldwide. The endeavor to diagnose stroke through biomechanical time-series data coupled with Artificial Intelligence (AI) poses a formidable challenge, especially amidst constrained participant numbers. The challenge escalates when dealing with small datasets, a common scenario in preliminary medical research. While recent advances have ushered in few-shot learning algorithms adept at handling sparse data, this paper pioneers a distinctive methodology involving a visualization-centric approach to navigating the small-data challenge in diagnosing stroke survivors based on gait-analysis-derived biomechanical data. Employing Siamese neural networks (SNNs), our method transforms a biomechanical time series into visually intuitive images, facilitating a unique analytical lens. The kinematic data encapsulated comprise a spectrum of gait metrics, including movements of the ankle, knee, hip, and center of mass in three dimensions for both paretic and non-paretic legs. Following the visual transformation, the SNN serves as a potent feature extractor, mapping the data into a high-dimensional feature space conducive to classification. The extracted features are subsequently fed into various machine learning (ML) models like support vector machines (SVMs), Random Forest (RF), or neural networks (NN) for classification. In pursuit of heightened interpretability, a cornerstone in medical AI applications, we employ the Grad-CAM (Class Activation Map) tool to visually highlight the critical regions influencing the model’s decision. Our methodology, though exploratory, showcases a promising avenue for leveraging visualized biomechanical data in stroke diagnosis, achieving a perfect classification rate in our preliminary dataset. The visual inspection of generated images elucidates a clear separation of classes (100%), underscoring the potential of this visualization-driven approach in the realm of small data. This proof-of-concept study accentuates the novelty of visual data transformation in enhancing both interpretability and performance in stroke diagnosis using limited data, laying a robust foundation for future research in larger-scale evaluations.