RGCC Promotes Adipocyte Thermogenesis by Modulating Pgc1α Expression

adaptive Abstract Brown and beige adipocytes dissipate energy in a non-shivering thermogenesis manner, exerting beneficial impact on metabolic homeostasis. RGCC (protein regulator of cell cycle) is BAT-enriched protein, while its role in thermogenic adipocytes remains unknown. RGCC is upregulated by acute cold challenge or β3 agonist in BAT and iWAT. Lack of RGCC constrains expression of a set of thermogenic genes in brown and beige adipocytes. Conversely, ectopic expression of RGCC drives a full of program of thermogenesis and promotes browning. Pgc1α knockdown obviously prevents expression of RGCC-elicited thermogenic genes. Together, these findings uncover that physiological role for RGCC-mediated activation of the thermogenic program in adipocytes.