代谢相关(非酒精性)脂肪肝患者肠道微生物群短链脂肪酸生成活性低与高胆固醇血症和肝纤维化相关

IF 0.9 Q4 GASTROENTEROLOGY & HEPATOLOGY Gastrointestinal disorders (Basel, Switzerland) Pub Date : 2023-10-30 DOI:10.3390/gidisord5040038
Xinlu Cao, Oksana Zolnikova, Roman Maslennikov, Maria Reshetova, Elena Poluektova, Arina Bogacheva, Maria Zharkova, Vladimir Ivashkin
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引用次数: 0

摘要

本研究的目的是研究代谢相关脂肪性肝病(MAFLD)患者肠道微生物群的短链脂肪酸(SCFA)活性。采用气液色谱法测定短链脂肪酸(SCFAs)的含量和光谱。采用FIB-4指数和弹性成像评估肝纤维化。在42名非肝硬化的MAFLD患者中,24名患者的粪便SCFA水平较高(H组),18名患者的粪便SCFA水平较低(L组)。H组患者的血清尿酸、总胆固醇和LDL胆固醇水平较低,但BMI高于L组。L组中所有患者和H组中仅有37.9%的患者存在高胆固醇血症。在高胆固醇血症患者中,SCFAs水平低于无高胆固醇血症患者。H组患者肝纤维化发生率低于L组,H组患者肝纤维化发生率为50.0%,L组患者肝纤维化发生率为92.3%(≥F2)。肝纤维化显著的患者粪便中scfa水平较低,尤其是醋酸盐和丁酸盐。粪便SCFA水平与γ -谷氨酰转移酶、总胆红素水平、BMI和血小板计数呈正相关,与FIB-4、肝脏硬度、血清总胆固醇和LDL胆固醇水平呈负相关。
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Low Short-Chain-Fatty-Acid-Producing Activity of the Gut Microbiota Is Associated with Hypercholesterolemia and Liver Fibrosis in Patients with Metabolic-Associated (Non-Alcoholic) Fatty Liver Disease
The aim of this study was to investigate the short-chain fatty acid (SCFA) activity of the gut microbiota of patients with metabolic-associated fatty liver disease (MAFLD). The level and spectrum of short-chain fatty acids (SCFAs) were determined via gas–liquid chromatography. Liver fibrosis was assessed using the FIB-4 index and elastography. Among 42 non-cirrhotic MAFLD patients, 24 had high fecal SCFA levels (group H) and 18 had low fecal SCFA levels (group L). Patients in group H had lower serum uric acid, total cholesterol, and LDL cholesterol levels but a higher BMI than those in group L. All patients in group L and only 37.9% of those in group H were found to have hypercholesterolemia. In patients with hypercholesterolemia, the level of SCFAs was lower than that in patients without hypercholesterolemia. Patients in group H had less liver fibrosis than patients in group L. A total of 50.0% of the patients in group H and 92.3% of those in group L had significant liver fibrosis (≥F2). Patients with significant liver fibrosis had lower levels of fecal SCFAs—particularly acetate and butyrate. The fecal SCFA levels were positively correlated with gamma-glutamyl transferase, total bilirubin levels, BMI, and platelet count and were negatively correlated with FIB-4, liver stiffness, serum total, and LDL cholesterol levels.
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