{"title":"抑郁症遗传动物模型雌性WKY株海马NF-kB和JAK2/STAT3信号异常","authors":"Bojana Stefanović, Kristina Virijević, Nataša Spasojević, Harisa Ferizović, Milica Janković, Perica Vasljević, Slađana Dronjak","doi":"10.5937/kgjsci2345149s","DOIUrl":null,"url":null,"abstract":"Depression is a serious disorder with a large impact on both an individual's quality of life and society as a whole. This study aimed to evaluate the potential involvement of nuclear factor kappa-B (NF-kB) and the Janus activated kinase (JAK) and Signal transducer and activator of transcription proteins (STAT) signaling pathway in the pathogenesis of genetically predisposed depression in female rats. The obtained results showed increased phosphorylation in JAK2 and STAT3, and increased protein levels of NF-kB in the hippocampus of Wistar Kyoto rats compared to Wistar rats. These results suggest that disturbance in these pathways could have a significant role in the pathophysiology of genetically predisposed depression in females.","PeriodicalId":17829,"journal":{"name":"Kragujevac Journal of Science","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Dysregulation of NF-kB and JAK2/STAT3 signaling in the hippocampus of female WKY strain, a genetic animal model of depression\",\"authors\":\"Bojana Stefanović, Kristina Virijević, Nataša Spasojević, Harisa Ferizović, Milica Janković, Perica Vasljević, Slađana Dronjak\",\"doi\":\"10.5937/kgjsci2345149s\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Depression is a serious disorder with a large impact on both an individual's quality of life and society as a whole. This study aimed to evaluate the potential involvement of nuclear factor kappa-B (NF-kB) and the Janus activated kinase (JAK) and Signal transducer and activator of transcription proteins (STAT) signaling pathway in the pathogenesis of genetically predisposed depression in female rats. The obtained results showed increased phosphorylation in JAK2 and STAT3, and increased protein levels of NF-kB in the hippocampus of Wistar Kyoto rats compared to Wistar rats. These results suggest that disturbance in these pathways could have a significant role in the pathophysiology of genetically predisposed depression in females.\",\"PeriodicalId\":17829,\"journal\":{\"name\":\"Kragujevac Journal of Science\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Kragujevac Journal of Science\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5937/kgjsci2345149s\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Kragujevac Journal of Science","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5937/kgjsci2345149s","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
抑郁症是一种严重的疾病,对个人的生活质量和整个社会都有很大的影响。本研究旨在探讨核因子κ b (NF-kB)、Janus活化激酶(JAK)和转录蛋白信号转导和激活因子(STAT)信号通路在雌性大鼠遗传易感性抑郁症发病中的潜在作用。结果显示,与Wistar大鼠相比,Wistar Kyoto大鼠海马中JAK2和STAT3磷酸化水平升高,NF-kB蛋白水平升高。这些结果表明,这些通路的紊乱可能在女性遗传易感性抑郁症的病理生理中起重要作用。
Dysregulation of NF-kB and JAK2/STAT3 signaling in the hippocampus of female WKY strain, a genetic animal model of depression
Depression is a serious disorder with a large impact on both an individual's quality of life and society as a whole. This study aimed to evaluate the potential involvement of nuclear factor kappa-B (NF-kB) and the Janus activated kinase (JAK) and Signal transducer and activator of transcription proteins (STAT) signaling pathway in the pathogenesis of genetically predisposed depression in female rats. The obtained results showed increased phosphorylation in JAK2 and STAT3, and increased protein levels of NF-kB in the hippocampus of Wistar Kyoto rats compared to Wistar rats. These results suggest that disturbance in these pathways could have a significant role in the pathophysiology of genetically predisposed depression in females.