反相高效液相色谱法建立富马酸喹硫平原料药及剂型的分析方法并进行验证

IF 0.3 Q4 CHEMISTRY, MULTIDISCIPLINARY Oriental Journal Of Chemistry Pub Date : 2023-08-30 DOI:10.13005/ojc/390430

Siva Sanker Reddy Lingareddygari*, Nageswara Rao Ravikrindhi

{"title":"反相高效液相色谱法建立富马酸喹硫平原料药及剂型的分析方法并进行验证","authors":"Siva Sanker Reddy Lingareddygari*, Nageswara Rao Ravikrindhi","doi":"10.13005/ojc/390430","DOIUrl":null,"url":null,"abstract":"RP-HPLC method developed is a simple, precise and functional technique for the calculation of amount of Quetiapine fumarate from marketed tablets and bulk form. The RP-HPLC analysis was carried out on Hyper chrome ODS-BP 5µm column (4.6mm × 200mm) using a mobile phase 0.1% Orthophoshoric acid and Acetonitrile (80:20v/v) with pH 5.5. Quetiapine fumarate quantified by using UV detector at 210nm. The retention time of the Quetiapine fumarate was found to be 2.6 min. The linearity of the drug concentration ranges from 20-400µg/ml. The detection and quantification limits were intended at 3.70µg/ml and 12.35µg/ml. The precision, accuracy, specificity, robustness and degradation studies were validated.","PeriodicalId":19599,"journal":{"name":"Oriental Journal Of Chemistry","volume":"30 1","pages":"0"},"PeriodicalIF":0.3000,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Analytical Method Development and Validation of Quetiapine Fumarate in API and Dosage form by Using RP–HPLC\",\"authors\":\"Siva Sanker Reddy Lingareddygari*, Nageswara Rao Ravikrindhi\",\"doi\":\"10.13005/ojc/390430\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"RP-HPLC method developed is a simple, precise and functional technique for the calculation of amount of Quetiapine fumarate from marketed tablets and bulk form. The RP-HPLC analysis was carried out on Hyper chrome ODS-BP 5µm column (4.6mm × 200mm) using a mobile phase 0.1% Orthophoshoric acid and Acetonitrile (80:20v/v) with pH 5.5. Quetiapine fumarate quantified by using UV detector at 210nm. The retention time of the Quetiapine fumarate was found to be 2.6 min. The linearity of the drug concentration ranges from 20-400µg/ml. The detection and quantification limits were intended at 3.70µg/ml and 12.35µg/ml. The precision, accuracy, specificity, robustness and degradation studies were validated.\",\"PeriodicalId\":19599,\"journal\":{\"name\":\"Oriental Journal Of Chemistry\",\"volume\":\"30 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.3000,\"publicationDate\":\"2023-08-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Oriental Journal Of Chemistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.13005/ojc/390430\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Oriental Journal Of Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.13005/ojc/390430","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

摘要

建立了一种简便、准确、实用的富马酸喹硫平片剂和原料药用量计算方法。色谱柱为Hyper chrome ODS-BP 5µm (4.6mm × 200mm)，流动相为0.1%正磷酸-乙腈(80:20v/v)， pH为5.5。用紫外检测器在210nm处定量测定富马酸喹硫平。富马酸喹硫平的保留时间为2.6 min，药物浓度线性范围为20 ~ 400µg/ml。检测限和定量限分别为3.70µg/ml和12.35µg/ml。精密度、准确度、特异性、稳健性和降解性研究得到了验证。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

Analytical Method Development and Validation of Quetiapine Fumarate in API and Dosage form by Using RP–HPLC

RP-HPLC method developed is a simple, precise and functional technique for the calculation of amount of Quetiapine fumarate from marketed tablets and bulk form. The RP-HPLC analysis was carried out on Hyper chrome ODS-BP 5µm column (4.6mm × 200mm) using a mobile phase 0.1% Orthophoshoric acid and Acetonitrile (80:20v/v) with pH 5.5. Quetiapine fumarate quantified by using UV detector at 210nm. The retention time of the Quetiapine fumarate was found to be 2.6 min. The linearity of the drug concentration ranges from 20-400µg/ml. The detection and quantification limits were intended at 3.70µg/ml and 12.35µg/ml. The precision, accuracy, specificity, robustness and degradation studies were validated.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Oriental Journal Of Chemistry CHEMISTRY, MULTIDISCIPLINARY-

自引率

20.00%

发文量

172

期刊介绍： Oriental Journal of Chemistry was started in 1985 with the aim to promote chemistry research. The journal consists of articles which are rigorously peer-reviewed. The journal was indexed in Emerging Science citation index in 2016. The Editorial board member consists of eminent international scientist in all fields of Chemistry. Details of each member and their contact information is mentioned in website. The journal has thorough ethics policies and uses plagiarism detection software(ithenticate) to screen each submission. The journal has recently partnered with publons as a part of making our reviews more transparent. The journal has recently incorporated PlumX for article level matrix. The journal is promoting research on all social and academic platforms mentioned in PlumX guidelines. The journal uses google maps to improve on the geographical distribution of Editorial board members as well as authors.