在克里米亚使用焦痂拭子 DNA 诊断 Conorii 亚种 Conorii 立克次体感染:病例报告

Emine E. Alieva , Muniver T. Gafarova , Eugene I. Bondarenko , Igor A. Dovgan , Irina I. Osiptchuk , Marina E. Eremeeva
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引用次数: 0

摘要

自 20 世纪 30 年代起,克里米亚半岛就出现了地中海斑疹热(MSF)的临床诊断。我们描述了一名来自克里米亚的老年患者最近的病情,该患者出现了典型的三联地中海斑疹热症状,即发热、斑丘疹和焦痂。通过实时聚合酶链式反应(real-time PCR)和4个立克次体蛋白基因测序,临床诊断被确诊为立克次体病。引起临床疾病的菌株被定性为立克次体科诺里亚种科诺里马利什7号。该报告证实了焦痂拭子材料作为DNA来源在基于PCR的诊断中的实用性,可帮助及时治疗和管理患者。
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Use of eschar swab DNA to diagnose Rickettsia conorii subspecies conorii infection in Crimea: A case report

Mediterranean spotted fever (MSF) has been diagnosed clinically in the Crimean Peninsula since the 1930s. We describe the recent illness of an elderly patient from Crimea who had developed a classic triad of MSF symptoms consisting of fever, maculopapular rash, and eschar. Clinical diagnosis of rickettsiosis was confirmed using real-time PCR and sequencing of 4 Rickettsia protein genes. The strain causing clinical illness was characterized as Rickettsia conorii subspecies conorii Malish 7. This report corroborates the utility of eschar swab material as a source of DNA for PCR-based diagnostics that enables timely patient treatment and management.

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