{"title":"活细胞的自主性,进化的驱动力","authors":"Ford Brian J","doi":"10.17352/jbm.000040","DOIUrl":null,"url":null,"abstract":"Conventional biologists and medical doctors conceptualize the body as divided into cells. It is construed as a bag of organs, with one of everything down the center, and two of everything down the sides. My alternative view is the body as a community of autonomous living cells whose choreographed cohesion gives rise to the phenomenon we know as the body. Science reduces multicellular life to the biochemical interplay of its components, and systems biology to a concatenation of subunits acting according to the laws of chemistry and physics. Current studies of living cells concentrate on the subcellular components since mitochondria were designated the “powerhouse of the cell” though they can be seen to move, migrate, and respond to stimuli. Although we understand cells in communities and the organelles within each cell, we ignore the lives lived by individual cells as they conduct themselves in heuristic (decision-making) and in motivating evolutionary progress. Here we review original observations on the behavior of living cells and conclude that they are essential drivers of coordinated community cohesion.","PeriodicalId":48617,"journal":{"name":"Yale Journal of Biology and Medicine","volume":null,"pages":null},"PeriodicalIF":2.5000,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Autonomy of the Living Cell, Driving Force of Evolution\",\"authors\":\"Ford Brian J\",\"doi\":\"10.17352/jbm.000040\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Conventional biologists and medical doctors conceptualize the body as divided into cells. It is construed as a bag of organs, with one of everything down the center, and two of everything down the sides. My alternative view is the body as a community of autonomous living cells whose choreographed cohesion gives rise to the phenomenon we know as the body. Science reduces multicellular life to the biochemical interplay of its components, and systems biology to a concatenation of subunits acting according to the laws of chemistry and physics. Current studies of living cells concentrate on the subcellular components since mitochondria were designated the “powerhouse of the cell” though they can be seen to move, migrate, and respond to stimuli. Although we understand cells in communities and the organelles within each cell, we ignore the lives lived by individual cells as they conduct themselves in heuristic (decision-making) and in motivating evolutionary progress. Here we review original observations on the behavior of living cells and conclude that they are essential drivers of coordinated community cohesion.\",\"PeriodicalId\":48617,\"journal\":{\"name\":\"Yale Journal of Biology and Medicine\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2023-09-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Yale Journal of Biology and Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.17352/jbm.000040\",\"RegionNum\":3,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Yale Journal of Biology and Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.17352/jbm.000040","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOLOGY","Score":null,"Total":0}
Autonomy of the Living Cell, Driving Force of Evolution
Conventional biologists and medical doctors conceptualize the body as divided into cells. It is construed as a bag of organs, with one of everything down the center, and two of everything down the sides. My alternative view is the body as a community of autonomous living cells whose choreographed cohesion gives rise to the phenomenon we know as the body. Science reduces multicellular life to the biochemical interplay of its components, and systems biology to a concatenation of subunits acting according to the laws of chemistry and physics. Current studies of living cells concentrate on the subcellular components since mitochondria were designated the “powerhouse of the cell” though they can be seen to move, migrate, and respond to stimuli. Although we understand cells in communities and the organelles within each cell, we ignore the lives lived by individual cells as they conduct themselves in heuristic (decision-making) and in motivating evolutionary progress. Here we review original observations on the behavior of living cells and conclude that they are essential drivers of coordinated community cohesion.
期刊介绍:
The Yale Journal of Biology and Medicine (YJBM) is a graduate and medical student-run, peer-reviewed, open-access journal dedicated to the publication of original research articles, scientific reviews, articles on medical history, personal perspectives on medicine, policy analyses, case reports, and symposia related to biomedical matters. YJBM is published quarterly and aims to publish articles of interest to both physicians and scientists. YJBM is and has been an internationally distributed journal with a long history of landmark articles. Our contributors feature a notable list of philosophers, statesmen, scientists, and physicians, including Ernst Cassirer, Harvey Cushing, Rene Dubos, Edward Kennedy, Donald Seldin, and Jack Strominger. Our Editorial Board consists of students and faculty members from Yale School of Medicine and Yale University Graduate School of Arts & Sciences. All manuscripts submitted to YJBM are first evaluated on the basis of scientific quality, originality, appropriateness, contribution to the field, and style. Suitable manuscripts are then subject to rigorous, fair, and rapid peer review.