活细胞的自主性,进化的驱动力

IF 2.5 3区 工程技术 Q2 BIOLOGY Yale Journal of Biology and Medicine Pub Date : 2023-09-09 DOI:10.17352/jbm.000040
Ford Brian J
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引用次数: 0

摘要

传统的生物学家和医生将身体划分为细胞。它被解释为一袋器官,其中一个器官在中间,两个器官在两边。我的另一种观点是,身体是一个由自主的活细胞组成的社区,这些细胞精心编排的凝聚力产生了我们所知的身体现象。科学将多细胞生命归结为其组成部分之间的生物化学相互作用,将系统生物学归结为根据化学和物理定律作用的亚单位的串联。目前对活细胞的研究主要集中在亚细胞成分上,因为线粒体被认为是“细胞的动力源”,尽管它们可以移动、迁移和对刺激作出反应。虽然我们了解群体中的细胞和每个细胞内的细胞器,但我们忽略了单个细胞在启发式(决策)和推动进化过程中所过的生活。在这里,我们回顾了对活细胞行为的原始观察,并得出结论,它们是协调社区凝聚力的重要驱动力。
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Autonomy of the Living Cell, Driving Force of Evolution
Conventional biologists and medical doctors conceptualize the body as divided into cells. It is construed as a bag of organs, with one of everything down the center, and two of everything down the sides. My alternative view is the body as a community of autonomous living cells whose choreographed cohesion gives rise to the phenomenon we know as the body. Science reduces multicellular life to the biochemical interplay of its components, and systems biology to a concatenation of subunits acting according to the laws of chemistry and physics. Current studies of living cells concentrate on the subcellular components since mitochondria were designated the “powerhouse of the cell” though they can be seen to move, migrate, and respond to stimuli. Although we understand cells in communities and the organelles within each cell, we ignore the lives lived by individual cells as they conduct themselves in heuristic (decision-making) and in motivating evolutionary progress. Here we review original observations on the behavior of living cells and conclude that they are essential drivers of coordinated community cohesion.
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来源期刊
Yale Journal of Biology and Medicine
Yale Journal of Biology and Medicine Biochemistry, Genetics and Molecular Biology-General Biochemistry,Genetics and Molecular Biology
CiteScore
5.00
自引率
0.00%
发文量
41
期刊介绍: The Yale Journal of Biology and Medicine (YJBM) is a graduate and medical student-run, peer-reviewed, open-access journal dedicated to the publication of original research articles, scientific reviews, articles on medical history, personal perspectives on medicine, policy analyses, case reports, and symposia related to biomedical matters. YJBM is published quarterly and aims to publish articles of interest to both physicians and scientists. YJBM is and has been an internationally distributed journal with a long history of landmark articles. Our contributors feature a notable list of philosophers, statesmen, scientists, and physicians, including Ernst Cassirer, Harvey Cushing, Rene Dubos, Edward Kennedy, Donald Seldin, and Jack Strominger. Our Editorial Board consists of students and faculty members from Yale School of Medicine and Yale University Graduate School of Arts & Sciences. All manuscripts submitted to YJBM are first evaluated on the basis of scientific quality, originality, appropriateness, contribution to the field, and style. Suitable manuscripts are then subject to rigorous, fair, and rapid peer review.
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