Psychopharmacological Activity of Chirata

The objective of the present study was to investigate the Psychopharmacological Activity of the ethanolic and methanolic extract of leaves of Swertia chirayita Roxb. ex Flem. in mice as a part of psychopharmacological screening of this plant, using different in vivo experimental models. The effects of the plant extract ethanolic and methanolic (250 mg/kg and 500 mg/kg respectively) on the central nervous system (CNS) was evaluated by forced swim test, plus maze method, Hole board test and spontaneous motor activity. The results revealed that the ethanolic extract of Swertia chirayita Roxb. ex Flem plant has showed better results as compared to methanolic extract. In the test studied for the Psychopharmacological Activity of ethanolic and methanolic extract of Swertia chirayita Roxb. ex Flem plant, using forced swim test, plus maze method, Hole board test and spontaneous motor activity it was revealed that the ethanolic extract at doses 250 mg/kg and 500mg/kg showed significantly (p<0.05). The overall results suggest that the ethanolic extract of Swertia chirayita Roxb. ex Flem plant contains flavonoids which may possess significant psychopharmacological activity.