磁回收合成吡喃吡唑的纳米催化剂:CoFe2O4@SiO2-HClO4

Nikita Vinod Thakare, Anand Shankar Aswar, Nilesh Govindrao Salunkhe
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引用次数: 0

摘要

多杂环体系具有重要的药理和生物活性。本文研究了芳基醛、丙二腈和5-甲基-2,4-二氢- 3h -吡唑-3- 1在微波辅助下合成吡唑[2,3-c]。该反应是在无溶剂条件下进行的,有一种新的磁性可回收纳米催化剂(CoFe2O4@SiO2-HClO4)存在。所报道的方案具有环境友好、快速、廉价、高原子经济性和阶梯经济性、易操作等优点。该纳米催化剂制备方法简单、易于磁回收、可重复使用四次是其显著特点。对合成的化合物进行了对大肠杆菌和金黄色葡萄球菌的抑菌活性测试。所有合成的化合物都显示出良好的生物活性,可能成为生物科学领域潜在的抗菌候选物质。
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Magnetically recoverable nanocatalyst for the synthesis of pyranopyrazoles: CoFe2O4@SiO2-HClO4
The multiheterocyclic ring system shows valuable pharmaceutical and biological activities. In the present study, a microwave-assisted three-component reaction between aryl aldehyde, malononitrile, and 5-methyl-2,4-dihydro-3H-pyrazole-3-one led to the synthesis of pyrano[2,3-c]pyrazoles has been described. The reaction was carried out under solvent-free conditions in the presence of a new magnetically recoverable nanocatalyst (CoFe2O4@SiO2-HClO4). The reported protocol offers several advantages such as being environmentally benign, being rapid, inexpensive, having high atom and step economy, and being facile. The simple method of catalyst preparation, easy magnetic recovery, and reusability of the catalyst for four runs are notable features of the nanocatalyst. Antibacterial activity of all synthesized compounds was tested against Escherichia coli and Staphylococcus aureus. All synthesized compounds showed promising biological activity and may be used as a potential antibacterial candidate in biological science.
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